Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Parker, Sareeta; Murad, Emma

doi:10.1016/j.jaad.2009.01.031

Cited by 18 publications

(12 citation statements)

References 17 publications

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“…[4] In contrast all our cases showed a remarkable consistency in rapid and complete response to antileprosy treatment. These lesions had persisted for months, had even grown in size in case 2, and not responded to topical steroids and tretinoin in case 3.…”

Section: Discussionmentioning

confidence: 68%

“…Minocycline has been used in treatment of Alopecia Mucinosa, and minocycline in ROM may be the responsible for healing in case 3: Some papers[411] have shown good response of follicular mucinosis to minocycline, however, contrary results with very minimal or no improvement has also been reported in patients with Alopecia mucinosa who were treated with minocycline for more than 3 months. [12] Thus minocycline does not seem to give consistently good results in all cases of Alopecia mucinosa.…”

Section: Discussionmentioning

confidence: 99%

“…It may persist for months or years and no specific therapy has been found to be effective for patients with idiopathic alopecia mucinosa. [4]…”

Section: Introductionmentioning

confidence: 99%

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Alopecia mucinosa responding to antileprosy treatment: Are we missing something?

Joshi

Gopalani²

2013

Indian J Dermatol

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Three cases with single lesion of Alopecia mucinosa (follicular mucinosis) were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up. Two children, a boy aged 14 years and a girl aged 12 years presented themselves, each, with a single hypopigmented, hypoesthetic patch on the face. Clinically leprosy was suspected, however, skin biopsy from both patients revealed follicular mucinosis as the only pathological finding, without any granulomas. Based on clinical suspicion both were started on multi drug therapy (MDT) for leprosy with complete resolution of the lesions. The third case, male, aged 22 years presented with a single erythematous, hypoesthetic plaque on the forehead. This lesion had been diagnosed as follicular mucinosis with folliculo-tropic mycosis fungoides, in the USA. He too responded completely within 3 months with rifampicin, ofloxacin, minocycline (ROM) treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year. Follicular mucinosis as the only pathology may be seen in facial lesions of clinically suspected leprosy in children and young adults. Based on histological findings these cannot be diagnosed as leprosy and will be considered as Alopecia mucinosa. These lesions, however, are always single and show rapid and complete response to antileprosy treatment. The authors suggest that in regions endemic for leprosy, such as India, single lesion Alopecia mucinosa on the face in children and young adults should be given antileprosy treatment.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

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Alopecia mucinosa responding to antileprosy treatment: Are we missing something?

Joshi

Gopalani²

2013

Indian J Dermatol

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“…Sufficient long-term follow-up may be the ultimate criteria to assess the biologic nature of this entity. [4] Our patient began using topical corticosteroids with no real improvement. She was also offered photodynamic therapy, but her parents declined and decided to continue close monitoring and follow-up.…”

Section: Discussionmentioning

confidence: 98%

Follicular mucinosis

Lewars

Levin

Purcell

2013

Indian Dermatol Online J

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Follicular mucinosis is an uncommon inflammatory disorder that characteristically presents as follicular papules and/or indurated plaques. The face, neck, and scalp are the most frequently affected sites, although lesions may occur on any site of the body. Histologically, the disorder is characterized by mucin deposition in the follicular epithelium. The condition is frequently divided into primary and secondary forms, with the latter form frequently associated with mycosis fungoides. In this case report, we describe a child with follicular mucinosis of the back and trunk and discuss the clinical variants, histopathological pattern, and treatment options.

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“…Several therapeutic modalities have been reported with variable results: topical corticoids, intralesional or oral, topical retinoids, oral isotretinoin, dapsone, indomethacin, minocycline, PUVA, cyclophosphamide and methotrexate, but no drug has a consistent result and the evaluation is difficult since there may be spontaneous involution. 7,8,9 Treatment of secondary form is the treatment of the associated disorder.…”

Section: Discussionmentioning

confidence: 99%

Follicular mucinosis - Case report

Passos

Zuchi

Fabre

et al. 2014

An. Bras. Dermatol.

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Follicular mucinosis, also known as alopecia mucinosa, is a cutaneous mucinosis histologically characterized by accumulation of dermal type mucin in the pilosebaceous follicle and sebaceous glands. It presents in two forms, a primary or idiopathic form and a secondary form associated with various benign or malignant processes. Among the malignant processes, the main association is with mycosis fungoides. The frequent overlap of clinical, histopathological, immunohistochemical and molecular biology characteristics makes the correct classification of these conditions difficult, therefore a long follow-up of all cases is recommended. We report the case of an adolescent with disseminated lesions and discuss the difficulty of early identification of secondary follicular mucinosis associated with cutaneous lymphoma.

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Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Cited by 18 publications

References 17 publications

Alopecia mucinosa responding to antileprosy treatment: Are we missing something?

Alopecia mucinosa responding to antileprosy treatment: Are we missing something?

Follicular mucinosis

Follicular mucinosis - Case report

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