Primary extraskeletal Ewing's sarcoma of the maxillary sinus

Yaprak, Neslihan; Toru, Havva Serap; Özbudak, İrem Hicran; Derin, Alper Tunga

doi:10.1016/j.bjorl.2016.03.014

Cited by 6 publications

(5 citation statements)

References 9 publications

(13 reference statements)

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“…Imaging evaluation required in monitoring the disease. Computed tomography is used to monitor bone destruction and mass propagation fields, while MRI is an ideal method for the evaluation of soft tissue involvement around the primary lesion [12]. In this case, a suspicious residual lesion was detected in the left maxillary sinus with evidence of bony resorption in the medial wall of maxillary sinus showed in repeated CECT.…”

Section: Discussionmentioning

confidence: 88%

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A case report of rare isolated Ewing sarcoma of left maxillary sinus

Hamid

Arepen

Hassan

et al. 2020

Egypt J Otolaryngol

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Background: Ewing sarcoma is a malignant round cell neoplasm and categorized as part of Ewing family tumor (EFT). Only 1-4% of all Ewing sarcomas are primarily located in the head and neck region and the isolated primary sinonasal sarcoma represents a rare entity. This case was reported due to its rarity and dilemma in diagnosis of recurrent post-treatment. Case presentation: We report a rare case of isolated left maxillary sinus Ewing sarcoma, presented with frequent unprovoked epistaxis, nasal blockage, and rhinorrhea from the left nostril for more than 2 years. Histopathological and immunohistochemical studies performed on the tissue taken from the left nasal mass confirmed Ewing sarcoma. He responded well to the 9 cycles of chemotherapy, evidenced by regression of mass from repeated CECT. However, the post-treatment scan showed multifocal nodular mucosal thickening involving the medial, anterior, and lateral walls of the maxillary sinus with corresponding bony resorption of the medial wall, raising a suspicion of residual disease. As such, he underwent endoscopic medial maxillectomy, which intraoperative findings revealed mild thickening of normal mucosa within the left maxillary sinus and histopathological examination showed no evidence of malignant cell. He showed no signs of recurrence during subsequent follow-up. Conclusion: As a conclusion, in a case of suspicious residual or recurrent disease detected post-chemotherapy, MRI is an option to differentiate between mucosal thickening and residual tumor. However, the role of surgical resection is equally important in assisting the tissue diagnosis and ensures a better local control, perhaps can increase the survival rate.

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Section: Discussionmentioning

confidence: 88%

“…The patient was reported to have no recurrence in 2 years upon completion treatment [4]. On the other hand, there was a reported case of recurrence post initial surgical excision and chemotherapy which required a second surgery for local control [12].…”

Section: Discussionmentioning

confidence: 99%

A case report of rare isolated Ewing sarcoma of left maxillary sinus

Hamid

Arepen

Hassan

et al. 2020

Egypt J Otolaryngol

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“…After clinical examination, imaginological exams are usually recommended to characterize the neoplasia and to understand its relationship with neighboring structures (Olson et al, 2018). According Several other lesions mainly of neoplastic origin, such as lymphoma, rhabdomyosarcoma, and synovial sarcoma are a challenge for the differential diagnosis with ES (Huh et al, 2015;Yaprak et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The imaginological appearance of ES depends on the affected site and is not pathognomonic of ES. Several other lesions mainly of neoplastic origin, such as lymphoma, rhabdomyosarcoma, and synovial sarcoma are a challenge for the differential diagnosis with ES (Huh et al, 2015; Yaprak et al, 2019). In this sense, the investigation of the characteristics of the lesions on imaging exams and their relation to adjacent structures is vital for an adequate evaluation of the case and for planning the biopsy procedure and treatment.…”

Section: Discussionmentioning

confidence: 99%

Ewing's sarcoma of the head and neck: A systematic review

et al. 2023

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ObjectiveThe aim of the present study was to conduct a systematic review of head and neck Ewing sarcoma (ES) concerning patients' demographic and clinical features, histopathological findings, treatment, follow‐up, and survival rate.Materials and MethodsAn electronic search was undertaken in four databases. Articles describing case reports or case series were included. Outcomes were evaluated by the Kaplan–Meier method along with Cox regression.ResultsThe search yielded 186 studies describing 227 ES cases. The mean age was 22.7 years, and males were slightly more affected. Interestingly, more than half the cases were diagnosed up to 20 years. The respiratory tract was the most reported site, followed by the jawbones. Clinically, symptomatic swelling or nodules were described, with a mean duration of 4 months. Management involved multimodal treatment regimens. Local recurrence, lymph node and distant metastasis were observed in 10.7%, 12.6%, and 20.3% of cases, respectively. Statistical analysis revealed that older patients with distant metastasis had a lower overall survival rate (p < 0.05).ConclusionThis study provides an overall view of head and neck ES that can assist oral and maxillofacial pathologists with the diagnosis and extend the knowledge of surgeons and oncologists about this condition.

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“…Early and accurate diagnosis is essential for improved survival for patients with this tumour. However, despite extensive aggressive treatment strategies employed, it presents with a high recurrence rate of 50-80%, and a poor prognosis if not diagnosed in the early stages [5,8].…”

Section: Discussionmentioning

confidence: 99%

Ewing’s sarcoma of the mandibular condyle in a young adult: a rare case report

Kudva

Kumar

Nayak

et al. 2022

J Oral Med Oral Surg

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Introduction: Ewing’s sarcoma is a malignant, small, round, blue-cell tumour with metastatic potential that usually occurs in older children and young adults. Its occurrence in the jawbones is exceedingly rare and even rarer the in mandibular condyle. This case is being reported due to the extreme unique imaging finding of Ewing’s sarcoma arising in the mandible in a young male. Observation: A 22-year-old healthy male presented with a complaint of a progressive swelling in his right preauricular region. Magnetic resonance imaging showed a hyperintense lesion with the right ramus with loss of fat planes. True cut biopsy and histopathological examination of the lesion was suggestive of Ewing’s Sarcoma. Immunohistochemical analysis confirmed the diagnosis. Discussion: The most common presenting symptom of Ewing’s sarcoma in the head and neck region is a rapidly growing expansile mass along with pain, paraesthesia, and visual disturbances often mimicking odontogenic infections. Higher imaging modalities play a major role in the evaluation of the extent of the lesion and diagnosis. Conclusion: Prompt and pertinent treatment planning is critical for appropriate and timely management.

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Primary extraskeletal Ewing's sarcoma of the maxillary sinus

Cited by 6 publications

References 9 publications

A case report of rare isolated Ewing sarcoma of left maxillary sinus

A case report of rare isolated Ewing sarcoma of left maxillary sinus

Ewing's sarcoma of the head and neck: A systematic review

Ewing’s sarcoma of the mandibular condyle in a young adult: a rare case report

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