Primary extranodal non-Hodgkin′s lymphoma of oral cavity - A single centre retrospective study

Sirsath, Nagesh T; Lakshmaiah, K C; Das, Umesh; Dasappa, Lokanatha; Chennagiri, S Premlatha; Ramarao, Clementina

doi:10.4103/0973-1482.136024

Cited by 28 publications

(8 citation statements)

References 27 publications

(38 reference statements)

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“…Studies on the survival time for patients with DLBCL in the head and neck are controversial [24,36,37]; here, we added that lymphoma arising from the base of the tongue has a good prognosis. Lopez-Guillermo et al [36] showed that patients with DLBCL located on Waldeyer's ring (base of the tongue) often have a better prognosis than nodal DLBCL patients.…”

Section: Discussionmentioning

confidence: 99%

Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status

Ren

Cheng

et al. 2020

Diagn Pathol

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Objectives: Non-Hodgkin's lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. Methods: Seven cases were identified from the Pathological Registry Database at Peking Union Medical College Hospital (PUMCH). The study utilized immunochemistry, in situ hybridization (ISH), and gene rearrangement to confirm the disease and and performed a clinical follow up for each case. Results: All 7 lymphomas were localized at the base of the tongue. Six of the cases exhibited tongue base masses with smooth surface membranes. One case presented as multiple deep ulcers. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. The other two cases were mantle cell lymphoma (MCL) and peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). One of the DLBCL cases was positive for HPV DNA and diffusely expressed P16 protein. During the follow up period, the MCL patient and an elderly DLBCL patient died. The remaining five patients were alive through the end of follow up. Conclusions: Most lymphomas of the tongue base manifest as an endogenous mass without membranous change. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. With proper therapy, even late stage tongue base lymphomas can be suppressed and remain in remission.

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Section: Discussionmentioning

confidence: 99%

Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status

Ren

Cheng

et al. 2020

Diagn Pathol

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“…The diagnosis of oral lymphomas can be challenging because there is low clinical suspicion, leading to diagnostic errors and delayed treatment. 9 A careful assessment, knowledge about HIV infection and its oral manifestations will help correctly and promptly diagnosing malignant lesions, avoiding situations such as in our case, where the initial diagnosis was of a dental infection.…”

Section: Discussionmentioning

confidence: 72%

Oral plasmablastic lymphoma as the first manifestation of AIDS

Vale

Rogado

Carvalho

et al. 2017

An. Bras. Dermatol.

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Plasmablastic lymphoma is a non-Hodgkin lymphoma characterized by its plasmacytic differentiation and predilection for the oral cavity. It is among the lymphomas most commonly associated with AIDS. This report details a case of a HIV-positive patient with a 1-month history of an exophytic mass in the gingival area of the upper left quadrant. The diagnosis of plasmablastic lymphoma was made based on its histopathological and immunophenotypical features. She was treated with chemotherapy followed by autologous hematopoietic stem cell transplantation. Despite complete resolution of the lesion, the patient died of cardiorespiratory arrest. This case illustrates plasmablastic lymphoma as the first clinical manifestation of AIDS, highlighting the importance of differentiating between a potentially malignant lesion and other pathologic processes.

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“…Local volume increase, elastic-like mass formation, ulcerations, dental mobility, skin lesions and pain are often reported as symptoms in cases of Non-Hodgkin's Lymphoma in the oral cavity [14,15]. These clinical features may be confused with the clinical presentation of oral plasmacytoma, as can be observed in the case in question, then diagnosis of these conditions can be challenging, and when not done according to the recommended methods, can lead to errors and delays in the beginning of treatment [13].…”

Section: Discussionmentioning

confidence: 99%

“…Although the treatment of neoplasia belongs to hematologists and oncologists, the dental surgeon plays a fundamental role in the diagnosis of oral cavity lesions [13]. Therefore, well-founded doubts are essential to the diagnosis of oral plasmacytoma, avoiding delays in the diagnostic procedure that consequently lead to a decrease in survival rates [15].…”

Section: Discussionmentioning

confidence: 99%

Large Extramedullary Plasmacytoma in Oral Cavity in a patient with Lympho plasmacytic Non-Hodgkin's Lymphoma

Macêdo¹,

Melo²,

Vieira³

et al. 2018

IJHBD

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Plasmacyte neoplasms are characterized by monoclonal proliferation of plasma cells with production of immunoglobulin [1]. They may present as a single lesion (solitary plasmacytoma) or multiple lesions (multiple myeloma). Single lesions usually occur in bone (bone plasmacytoma) but may also occur in soft tissues (extramedullary plasmacytoma) [2]. Its etiology is unknown, being infrequent in the jaws [3, 4].

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Primary extranodal non-Hodgkin′s lymphoma of oral cavity - A single centre retrospective study

Cited by 28 publications

References 27 publications

Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status

Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status

Oral plasmablastic lymphoma as the first manifestation of AIDS

Large Extramedullary Plasmacytoma in Oral Cavity in a patient with Lympho plasmacytic Non-Hodgkin's Lymphoma

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