Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

Casella, Claudio; Villanacci, Vincenzo; D'Adda, Filippo; Codazzi, Manuela; Salerni, Bruno

doi:10.4137/cmo.s9180

Cited by 19 publications

(32 citation statements)

References 52 publications

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“…The most specific and important immunohistochemical marker is the KIT (CD117) protein, a tyrosine kinase growth factor receptor expressed in more than 95% of cases. More rarely, neoplasms with histology and immunohistochemistry similar to GISTs may occur outside the gastrointestinal tract (omentum, mesentery, and retroperitoneum) and are so-called extra-gastrointestinal stromal tumors (EGISTs) [10]. EGISTs arising in the retroperitoneum are extremely rare.…”

Section: Extra-gastrointestinal Stromal Tumormentioning

confidence: 99%

“…Gastrointestinal stromal tumors (GIST) represent less than 1% of all malignancies, but they are the most common mesenchymal neoplasms in the gastrointestinal tract (40% to 70% originate from the stomach, 20% to 40% from small intestine, 5% to 15% from the colon and rectum, and 5% from the esophagus) [10]. GIST arises from the wall of the gastrointestinal tract and is thought to originate from the interstitial cells of Cajal.…”

Section: Extra-gastrointestinal Stromal Tumormentioning

confidence: 99%

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The gamut of primary retroperitoneal masses: multimodality evaluation with pathologic correlation

Sangster

Migliaro²,

Heldmann

et al. 2016

Abdom Radiol

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The retroperitoneum is a large space where primary and metastatic tumors grow silently before clinical signs appear. Neoplastic retroperitoneal diseases may be solid or cystic, primary or secondary and range from benign to aggressive in behavior. Retroperitoneal neoplasms are notable for their widely disparate histologies. The solid primary retroperitoneal neoplasms are extremely uncommon and can be classified based on their tissue of origin into three main categories: mesodermal tumors, neurogenic tumors, and extragonadal germ cell tumors. These tumors can grow to a large size before clinical symptoms occur or become palpable. When symptoms do occur, they are nonspecific. The majority of these masses are malignant and imaging plays a pivotal role in the detection, staging, and pre-operative planning. Benign and malignant masses should be distinguished whenever possible to avoid unnecessary surgical procedures. Macroscopic fat, calcification, necrosis, vascularity, and neural foraminal widening are common imaging features helping for tumor differentiation. Meticulous cross-sectional imaging can triage the patient to the most appropriate therapy. Tumor morphology dictates imaging character, and biologic activity is reflected by positron emission tomography (PET). Complete surgical excision with tumor free margins is essential for long-term survival. Biopsy should be performed in consultation with surgical oncology to avoid complicating curative surgery. This pictorial essay illustrates the spectrum of multidetector computed tomography (MDCT) imaging findings in common and uncommon primary retroperitoneal masses, with an emphasis on cross-sectional imaging features for an adequate tumor characterization and staging.

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Section: Extra-gastrointestinal Stromal Tumormentioning

confidence: 99%

Section: Extra-gastrointestinal Stromal Tumormentioning

confidence: 99%

The gamut of primary retroperitoneal masses: multimodality evaluation with pathologic correlation

Sangster

Migliaro²,

Heldmann

et al. 2016

Abdom Radiol

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“…The origin of EGISTs remains to be elucidated; however, GISTs and EGISTs have been confirmed to share various clinicopathological and histological features (11). As the presence of GISTs have been observed in numerous organs, including the urinary bladder (21), prostate (22), uterus (23), gall bladder (24) and myocardium (25), it can be assumed that EGISTs originate from common precursor cells that are able to differentiate into ICC-derived neoplasms outside of the gastrointestinal tract during development (26). An alternative explanation is that this type of tumor originates from the pluripotent mesenchymal stem cells located outside the gastrointestinal tract (10).…”

Section: Discussionmentioning

confidence: 99%

Primary extragastrointestinal stromal tumor of the pleura: A case report

Zhang

Liu

et al. 2016

Oncology Letters

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Abstract. Gastrointestinal stromal tumors (GISTs) are the most common type of mesenchymal tumor of the gastrointestinal tract. The stomach and small intestine are the most common sites of occurrence. GISTs are mesenchymal neoplasms originating from the interstitial cells of Cajal (ICCs), and are characterized by positivity for cluster of differentiation (CD) 117, also known as proto-oncogene c-Kit. While the majority of GISTs develop in the alimentary tract, in rare cases they may also be found in extragastrointestinal tissues. This type of GIST is known as an extragastrointestinal stromal tumor (EGIST). Despite the fact that EGISTs have been reported in the mesentery, omentum and retroperitoneum, primary intrathoracic EGISTs, arising from the pleura or lungs, are rare. The patient presented in the current study was a 40-year-old man, who presented with a cough and pyrexia, with pleural effusion on the left side. Multiple nodules throughout the parietal pleura were identified by thoracoscopy and a diagnosis of primary GIST of pleura was established, since they were positive for CD117 and discovered on GIST-1 and there was no evidence of gastrointestinal tumors. Subsequently, the patient was administered with imatinib and had no signs of disease recurrence 2 years later.

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“…Gastrointestinal stromal tumour (GIST) is a non-epithelial neoplasm arising from the muscularis propria layer (interstitial cells of Cajal) of the GI tract, with characteristic exophytic growth patterns [104, 105]. Among the presentations of extra-gastrointestinal stromal tumours, most are found in the omentum and mesentery [104].…”

Section: Introductionmentioning

confidence: 99%

Radiological diagnosis of perinephric pathology: pictorial essay 2015

Mitreski

Sutherland

2017

Insights Imaging

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The perinephric space, shaped as an inverted cone, sits between the anterior and posterior renal fasciae. It can play host to a variety of clinical conditions encountered daily in the reporting schedule for a radiologist. Lesions may be classified and diagnosed based on their imaging characteristics, location and distribution. A broad range of differential diagnoses can be attributed to pathology sitting within this space, often without clinical signs or symptoms. An understanding of commonly encountered conditions affecting the perinephric space, along with characteristic imaging findings, can illustrate and often narrow the likely diagnosis. The aim of this essay is to describe commonly encountered neoplastic and non-neoplastic entities involving the perinephric space and to describe their key imaging characteristics.Teaching Point• Despite often a bulky disease, perinephric lymphoma does not produce obstruction or stenosis.• In primarily fatty masses, defects within the renal capsule likely represent angiomyolipoma.• Consider paraganglioma if biopsy is planned; biopsy may lead to catecholamine crisis.

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Primary Extra-gastrointestinal Stromal Tumor of Retroperitoneum

Cited by 19 publications

References 52 publications

The gamut of primary retroperitoneal masses: multimodality evaluation with pathologic correlation

The gamut of primary retroperitoneal masses: multimodality evaluation with pathologic correlation

Primary extragastrointestinal stromal tumor of the pleura: A case report

Radiological diagnosis of perinephric pathology: pictorial essay 2015

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