Primary extragastrointestinal stromal tumor of the pleura: A case report

Zhang, Cai‐Qing; Lu, Degan; Liu, Qingfa; Xiao, Wei

doi:10.3892/ol.2016.4344

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Gastrointestinal stromal tumors are the most common mesenchymal tumors originating in the digestive tract, with an annual incidence of 11‐19 per million . On rare occasions, they occur in extravisceral locations such as the omentum, mesentery, and retroperitoneum. However, even after a complete resection, a substantial proportion of patients experience disease recurrence, with an overall 5‐year survival of between 40% and 65% .…”

Section: Introductionmentioning

confidence: 99%

A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor

Ren

Cai

et al. 2018

Cancer Medicine

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Background and ObjectivesRecurrence and metastasis are the most important factors affecting the quality of life and survival rate of patients with gastrointestinal stromal tumors (GISTs). Accurate preoperative determination of the malignant degree of GISTs and the development of a reasonable treatment plan can effectively reduce the recurrence rate. CT is currently considered the preferred imaging modality for initial assessment. Until now, there have only been a few studies investigating the relationship between CT features and recurrence of GISTs. However, the value of CT features in prognostic assessment is still unclear. In this study, we attempted to investigate the prognostic significance of CT features and the Ki67 index in GISTs.MethodsWe retrospectively analyzed the clinicopathological and imaging data for 151 patients with a histopathological diagnosis of GIST who had received contrast‐enhanced CT examination and surgical resection at XinHua Hospital from October 2008 to December 2015 or Sir Run Run Shaw Hospital in 2017. Then, we explored the correlation among CT features, the Ki67 index, and risk stratification of GISTs. The correlation among CT features, the Ki67 index, and risk stratification was mainly analyzed using the Spearman rank correlation.ResultsThe incidence of high‐risk disease or metastasis was clearly higher in the group with Ki67 > 5% than that in the group with Ki67 ≤ 5% (P < 0.001). The Ki67 index was positively correlated with risk stratification (r = 0.558) or mitotic index (r = 0.619). CT imaging features including size, contour, and margin of the tumor were associated with the Ki67 index (r = 0.332, 0.333, and 0.302, respectively). The multivariate logistic regression analysis revealed that the tumor size [P = 0.043 Exp (B) = 1.150] and the presence of ulceration [P = 0.011, Exp (B) = 3.669] were effective variables in distinguishing between the groups with Ki67 ≤ 5% and >5%. The presence of necrosis or cystic degeneration, tumor contour, tumor margin, and pattern of enhancement were associated with risk stratification (r = 0.530, 0.501, 0.419, and 0.447, respectively).ConclusionsOur findings suggest that the Ki67 index is an effective complementation in predicting the prognosis of GISTs, and CT features including size, contour, and margin of the tumor, presence of necrosis or cystic degeneration, and pattern of enhancement provide evidence to support the importance of preoperative assessment.

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Section: Introductionmentioning

confidence: 99%

A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor

Ren

Cai

et al. 2018

Cancer Medicine

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“… 1 - 4 These tumors can arise in any part of the GI tract, but a higher burden has been observed in the stomach and small intestines. 2 , 6 , 7 , 12 , 14 Although extremely rare, eGISTs have been identified in the uterus, urinary bladder, retroperitoneum, omentum, mesentery, liver, pancreas, and pleura. 14 - 16 Gastrointestinal stromal tumors are usually found in individuals over the age of 50 years, with a slight male predominance.…”

Section: Discussionmentioning

confidence: 99%

A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen

Bathobakae,

Bashir,

Vera

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract and arise from the interstitial cells of Cajal in the mesenteric plexus. These tumors can originate in any part of the GI tract; however, a higher burden has been observed in the stomach and small intestines. Mesenteric GISTs are exceedingly rare, with unique clinicopathological features and a poorer prognosis. Herein, we describe a unique case of a 66-year-old female with a remote history of appendectomy who presented to the emergency room complaining of severe abdominal pain and vomiting. On imaging, the patient was found to have a large inflammatory mass associated with small bowel loops, and the pathology confirmed a mesenteric GIST. The tumor was resected, and the genomic test results confirmed the KIT (exon 11) mutation. Although the tumor had a low mitotic rate, the tumor was large enough to warrant the initiation of adjuvant imatinib mesylate for 36 months with regular bloodwork and imaging.

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“…Mesentery and omentum are common tumor sites of genuine primary EGISTs ( 91 , 92 ). Other rare and unusual locations are pancreas ( 93 ), prostate ( 94 ), and pleura ( 95 ). With rare and aggressive malignancy, patients with EGISTs often have comparatively poor survival outcome, classified as high-risk lesions ( 96 ).…”

Section: Surgical Management In Gastrointestinal Stromal Tumorsmentioning

confidence: 99%

Advances of endoscopic and surgical management in gastrointestinal stromal tumors

2023

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As one of the most common mesenchymal malignancies in the digestive system, gastrointestinal stromal tumors (GISTs) occur throughout the alimentary tract with diversified oncological characteristics. With the advent of the tyrosine kinase inhibitor era, the treatment regimens of patients with GISTs have been revolutionized and GISTs have become the paradigm of multidisciplinary therapy. However, surgery resection remains recognized as the potentially curative management for the radical resection and provided with favorable oncological outcomes. The existing available surgery algorithms in clinical practice primarily incorporate open procedure, and endoscopic and laparoscopic surgery together with combined operation techniques. The performance of various surgery methods often refers to the consideration of risk evaluation of recurrence and metastases; the degree of disease progression; size, location, and growth pattern of tumor; general conditions of selected patients; and indications and safety profile of various techniques. In the present review, we summarize the fundamental principle of surgery of GISTs based on risk assessment as well as tumor size, location, and degree of progress with an emphasis on the indications, strengths, and limitations of current surgery techniques.

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Primary extragastrointestinal stromal tumor of the pleura: A case report

Cited by 6 publications

References 25 publications

A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor

A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor

A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen

Advances of endoscopic and surgical management in gastrointestinal stromal tumors

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