Primary Ewing sarcoma/peripheral primitive neuroectodermal tumor of the vulva

Fong, Yaou; López‐Terrada, Dolores; Zhai, Qihui

doi:10.1016/j.humpath.2008.01.013

Cited by 33 publications

(24 citation statements)

References 11 publications

(19 reference statements)

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“…Increased or decreased expression of CD99 has been suggested to act as a marker of various kinds of tumors, including Ewing's sarcoma/primitive neuroectodermal tumors (Fong et al 2008), anaplastic large cell lymphoma (Buxton et al 2009), lymphoblastic lymphoma/leukemia (Kang and Dunphy 2006), rhabdomyosarcoma (Folpe et al 2002;Euscher et al 2008), ovarian tumors (Choi et al 2000), and stomach cancer Lee et al 2007). However, the clinical implication of CD99 in epithelial tumors including transitional cell carcinoma of urinary bladder has been rarely studied.…”

Section: Introductionmentioning

confidence: 99%

Protein expression and gene promoter hypermethylation of CD99 in transitional cell carcinoma of urinary bladder

Xuan

Kim

Lin

2010

J Cancer Res Clin Oncol

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Section: Introductionmentioning

confidence: 99%

Protein expression and gene promoter hypermethylation of CD99 in transitional cell carcinoma of urinary bladder

Xuan

Kim

Lin

2010

J Cancer Res Clin Oncol

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“…Extraosseous Ewing sarcoma (EES) commonly arises in soft tissues of trunk or extremities, especially chest wall and paravertebral region, but a few reported rare sites include larynx, nasal cavity, neck, lung, retroperitoneum, perineum and mediastinum [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…But there were available literature reporting relatively favourable outcome for extraosseous ES/PNET arising in cutaneous and other superficial site. Hence, prognosis basically depends on tumour size, superficial location, early detection, metastasis and complete surgical removal of the lesion [1].…”

Section: Discussionmentioning

confidence: 99%

Primary Ewing Sarcoma of Vulva: A Case Report and a Review of Literature

Kakoti

Sharma

Kataki

et al. 2017

Indian J Gynecol Oncolog

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Introduction Ewing sarcoma family of tumour represents a group of bone and soft-tissue tumours with variable neuroectodermal differentiation. Extraosseous Ewing sarcoma (EES) commonly arises in soft tissues of trunk or extremities with a few reported rare sites include larynx, nasal cavity, neck, lung, retroperitoneum, mediastinum and genital tract. Till now 28 cases of extraosseous Ewing sarcoma of vulva and vagina have been reported in the literature. Case Report We report 29th case of Ewing sarcoma vulva in sixth youngest, 16-year-old patient with third largest size tumour. Her all routine blood reports were found to be normal, and MRI showed highly vascular vulval mass with terminal urethral involvement. Tru-cut biopsy revealed uniform sheets of small round cells with geographical necrosis and perivascular clusters of tumour cells. Immunohistochemical staining demonstrated that the cells were focally positive for CK and vimentin and showed membranous positivity for CD99 and nuclear positivity for FLI1, whereas all other IHC markers to rule out differentials of small round cell tumour were negative. Based on HPE and IHC, which is polyimmunophenotypic, has confirmed the diagnosis of an ES/PNET. After ruling out for the metastatic lesions, 14 cycles of chemotherapy with compressed VDC/IE were planned, but after receiving her 1st cycle itself, she expired on 10th day of postchemotherapy. Conclusion EES is a rare fast growing aggressive tumour requiring ancillary techniques for exact diagnosis and multimodality treatment for better survival.

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“…16,18 Immunohistochemistry shows membranous positivity for CD99 and Fli-1 in a nuclear pattern. 16,20 A EwS / Fli-1 fusion transcript can be evidenced by polymerase chain reaction. 20 Treatment includes surgery, chemotherapy, and radiation.…”

Section: Ewing Sarcoma Of the Vulvamentioning

confidence: 99%

“…16,20 A EwS / Fli-1 fusion transcript can be evidenced by polymerase chain reaction. 20 Treatment includes surgery, chemotherapy, and radiation. 21 The prognosis is poor, with frequent development of recurrence and high mortality, mainly associated with respiratory failure due to early development of lung metastases.…”

Section: Ewing Sarcoma Of the Vulvamentioning

confidence: 99%

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

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Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety-eight percent of all vulvar tumors are benign and only 2% are malignant. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In Part 1 of this paper, we presented the most common forms of sarcoma of the vulva: leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, and rhabdomyosarcoma. The second part of this review will focus mainly on the rarest variants of vulvar sarcoma: low-grade fibromyxoid sarcoma, synovial sarcoma, monophasic synovial sarcoma, carcinosarcoma, Ewing sarcoma, myeloid sarcoma, dermatofibrosarcoma protuberans, malignant fibrous histiocytoma, angiomatoid fibrous histiocytoma, liposarcoma, malignant peripheral nerve sheath tumor, and malignant mesothelioma.

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Primary Ewing sarcoma/peripheral primitive neuroectodermal tumor of the vulva

Cited by 33 publications

References 11 publications

Protein expression and gene promoter hypermethylation of CD99 in transitional cell carcinoma of urinary bladder

Protein expression and gene promoter hypermethylation of CD99 in transitional cell carcinoma of urinary bladder

Primary Ewing Sarcoma of Vulva: A Case Report and a Review of Literature

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2

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