Primary Esophageal Lymphoma: Case Series and Review of the Literature

Chadha, Krishdeep S.; Hernandez‐Ilizaliturri, Francisco J.; Javle, Milind

doi:10.1007/s10620-006-3088-0

Cited by 19 publications

(10 citation statements)

References 30 publications

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“… 6 The most common subtypes of primary esophageal lymphomas reported are extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) 1 , 7 – 11 and diffuse large B-cell lymphoma. 12 – 14 Aside from B cell lymphomas, there were also 10 cases of T or NK-cell lymphoma 15 – 18 and 3 cases of Hodgkin lymphoma 19 , 20 reported. Most primary esophageal lymphomas arose in patients older than 50 years.…”

Section: Discussionmentioning

confidence: 99%

Primary Esophageal Extranasal NK/T Cell Lymphoma With Biphasic Morphology

Cao²,

Liu

et al. 2015

Medicine

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We report a case of esophageal extranasal NK/T cell lymphoma with biphasic morphologic features revealed by a deep large piecemeal biopsy.A 40-year-old man present with pharyngalgia, dysphagia, recurrent fever, and 5-kg weight loss for 8 months. Endoscopy demonstrated progressing longitudinal ulcers and mucosal bridges along the esophagus. The first and second biopsies obtained superficial mucosa with scattered bland-looking small lymphocytes. A subsequent large piecemeal snare abscission for biopsy showed atypical lymphoid cells infiltrating into the deep lamina propria and muscularis mucosae, whereas the superficial lamina propria was highly edematous with scant small lymphocytes. Immunohistochemical studies confirmed that both underlying atypical cells and superficial small lymphocytes were neoplastic, sharing an identical immunophenotype: positive for CD2, CD3, CD43, CD8, CD56, TIA-1 and granzyme B. Epstein-Barr virus–encoded small RNAs were found in both cells. The histologic findings were diagnostic of primary esophageal extranasal NK/T cell lymphoma. However, the patient developed bone marrow depression during chemotherapy and died of massive cerebral hemorrhage after the first cycle of chemotherapy.Primary esophageal extranodal NK/T cell lymphoma nasal type is extremely rare. We show the biphasic morphology of this disease, which highlights the importance of deep biopsy for accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary Esophageal Extranasal NK/T Cell Lymphoma With Biphasic Morphology

Cao²,

Liu

et al. 2015

Medicine

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“…Esophageal involvement by lymphoma is usually secondary to local spread from the stomach or the mediastinum [8] . Very few cases of primary esophageal lymphomas were reported in literature [6][7][8][9][10][11] . There are many morphological variants with most of the common being large B cell type and Non-Hodgkin's lymphoma [9] .…”

Section: Discussionmentioning

confidence: 99%

Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma

Malik

Baig²,

Ahmed³

et al. 2013

WJGE

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SJ is a 37-year-old male who presented with one year history of dysphagia, odynophagia and 15 pounds weight loss. He underwent endoscopic evaluation which showed mid esophageal ulcers. It was thought that the cause of the ulcer was the multivitamins and the patient was asked to stop them. Furthermore Esomeprazole therapy was also initiated. Patient's symptoms persisted but he did not seek any medical attention until about one year later. Meanwhile the patient reported additional 15 pounds of weight loss. We repeated upper endoscopy again which showed evidence of two chronic non bleeding irregular friable ulcerations seen in the mid esophagus, 31 cm from the incisors. Biopsies and frozen section were taken and sent for assessment to the Pathology lab. Immunoperoxidase studies on frozen sections showed the presence of IgM and for most plasma cells IgG. The microscopic and histologic findings were consistent with mucous associated lymphoid tissue lymphoma with plasmocytic differentiation. Computed tomographic scan done showed no evidence of spread to adjacent structures. The patient was referred to oncology and several cycles of radiation and Rituximab therapy were initiated which cured the disease. Subsequent endoscopies with blind biopsies were done which were negative for any neoplastic process. Key words: Lymphoma; Mucous associated lymphoid tissue; EsophagusCore tip: This is a case of a 37-year-old gentleman presenting with chronic esophageal ulcers. Endoscopic biopsy samples were taken. Immunohistochemistry and hematoxylin and eosin staining of the biopsy samples were consistent with mucous associated lymphoid tissue (MALT) lymphoma. There was no sign of disease process in the stomach, and radiological studies revealed no evidence of metastasis. In consideration of these findings a diagnosis of primary esophageal MALT lymphoma was made, which is an extremely rare occurrence. On the basis of our experiences we recommend keeping primary esophageal MALT lymphoma in the differential diagnosis of chronic esophageal ulcers that are resistant to conservative management.

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“…Primary esophageal lymphoma is rare, with no MCL reported except a case in cardiac-type glandular tissue replacement of the lower esophagus [1,2,5-7]. This case, reported by Reyes, contains the typical molecular features of MCL, CD5 staining, cyclin D1 staining, and chromosomal translocation [t(11;14)(q13;q32)] [2].…”

Section: Discussionmentioning

confidence: 99%

Mantle cell lymphoma-like solitary polypoid tumor of the esophagus: a case report

2009

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IntroductionPrimary mantle cell lymphoma of the esophagus is quite rare, and we report here a case of a submucosal polypoid tumor of the esophagus that was pathologically similar, but not identical, to mantle cell lymphoma.Case presentationA 66-year-old man underwent surgery in our hospital for a submucosal tumor of the esophagus. Histopathologically, the submucosal tumor uniformly showed a vague, nodular pattern composed of a regular proliferation of CD3-CD10-CD20+CD79a+bcl2+ small lymphoid cells with islands of abortive CD10+Ki67+ germinal centers, without evidence of marginal zone formation or lymphoepithelial lesions. These features were consistent with mantle cell lymphoma. However, the proliferating cells weakly expressed the D-type cyclins, IgD and IgM. The tumor was diagnosed as a “mantle cell lymphoma-like tumor”. Postoperative examination confirmed no tumour involvement in other organs. The patient was treated with rituximab postoperatively and has been disease free for more than 28 months after surgery.ConclusionThe present case might be regarded as a “hyperplastic change of the mantle zone” without the molecular features of mantle cell lymphoma, a case that adds to the limited clinicopathological data on B-lymphoproliferative diseases of the esophagus.

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Primary Esophageal Lymphoma: Case Series and Review of the Literature

Cited by 19 publications

References 30 publications

Primary Esophageal Extranasal NK/T Cell Lymphoma With Biphasic Morphology

Primary Esophageal Extranasal NK/T Cell Lymphoma With Biphasic Morphology

Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma

Mantle cell lymphoma-like solitary polypoid tumor of the esophagus: a case report

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