Primary diffuse large B-cell lymphoma of endometrium

Abstract

<p class="BodyText1">This article was designed to analyze the prognosis and to explore the clinical characteristics and treatment of a case of primary diffuse large B-cell lymphoma (DLBCL) of the endometrium, through a detailed report. <strong>Methods</strong>: This report was done by analyzing a case through its clinical features, pathological examination and immunophenotyping. We believe that this would allow us to forecast the prognosis of the case. <strong>Case Description</strong>: The patient was admitted because of irregular postmenopausal vaginal bleeding for more than a month. She underwent a series of surgical procedures that included abdominal hysterectomy, bilateral adnexectomy, pelvic lymph node dissection and enterolysis owing to the assessed pathological results after uterine curettage. The postoperative pathological results showed that it was a DLBCL. <strong>Conclusion</strong>: Primary DLBCL of the endometrium is rarely reported. Its diagnosis and differential diagnosis mainly depends on pathological examination and immunophenotyping. Radical surgery combined with chemotherapy may be an ideal mode of treatment. The prognosis of the disease has a varied range but radical surgery combined with chemotherapy may improve her quality of life and prolong her survival period.</p>

Primary Endometrial Diffuse Large B-cell Lymphoma: A Rare Disease and Diagnostic Challenge in an Asymptomatic Postmenopausal Woman

“…Primary involvement of the uterine cavity by lymphoid neoplasm is an extremely rare manifestation of the disease as the female genital tract is most often affected secondarily [ 5 , 6 ]. Primary endometrial lymphomas usually affect postmenopausal women [ 7 , 8 ]. Patients tend to present with abnormal vaginal bleeding such as menorrhagia, postmenopausal bleeding, or abnormal vaginal discharge [ 9 ].…”

“…Criteria that must be fulfilled for diagnosis of a primary endometrial lymphoma, as proposed by Fox et al, include the following: confinement of the disease to the uterus at the time of the first diagnosis, no identifiable leukemia on a full blood count, no evidence of disease at other sites in the body, and a period of a number of months passing between the identification of a secondary site of involvement and the initial tumor site [ 6 , 7 , 10 ]. In our case, the tumor was confined to the uterus at the time of diagnosis with no evidence of nodal and bone marrow involvement, thus fulfilling the criteria.…”

Diffuse large B-cell lymphoma of the endometrium: an unusual site for primary presentation

“…1,5,8 Lymphomas primarily arising in the uterus are however, extremely rare but, relatively speaking, the female genital tract may be more often secondarily affected by lymphoma. 5,9,10 The cervix has been identified as the site within the female genital tract that is most often primarily effected by a lymphoma. 5,11,12 Primary endometrial lymphomas usually arise in post-menopausal females.…”