Primary cutaneous infection due to Microascus cirrosus: a case report

Gao, Lujuan; Chen, Junjun; Gao, Di; Li, Ming

doi:10.1186/s12879-018-3535-5

Cited by 6 publications

(6 citation statements)

References 5 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although Microascus is commonly found in different habitats and decaying organic matter, except for one case which was later reclassified as M. gracilis , only five publications concerning M. cirrosus infections have been reported to date [ 3 , 5 , 6 ]. In addition, respiratory infection was involved in just three immunosuppressed patients, with two received BMT for acute myelogenous leukemia and one underwent bilateral lung transplant for severe emphysema [ [7] , [8] , [9] ].…”

Section: Discussionmentioning

confidence: 99%

“…These genera are widely distributed in the natural environment, such as soil, animal dung and other organic matter [ 1 , 2 ]. In recent decades, Microascus species have been found to be pathogenic, particularly in immunocompromised hosts who have hematologic malignancies or those who have undergone solid organ or bone marrow transplantation (BMT) [ 3 , 4 ]. We describe the first case of pulmonary infection caused by Microascus cirrosus in an immunocompetent patient.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary Microascus cirrosus infection in an immunocompetent patient with bronchiectasis: A case report

Liu

Kong

Hua

et al. 2021

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

Microascus species are widely distributed and rarely cause invasive infection in humans. Here we report a case of lung Microascus cirrosus infection in an immunocompetent patient with bronchiectasis. While on systemic voriconazole and aerosolized amphotericin B for three months, the patient's overall condition improved. This case report highlights the possibility of rare pathogen infection occurred in a bronchiectasis patient, as well as the importance of accurate diagnosis and individualized therapy of pulmonary Microascus infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary Microascus cirrosus infection in an immunocompetent patient with bronchiectasis: A case report

Liu

Kong

Hua

et al. 2021

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

show abstract

“…This is generally consistent with the results of in vitro drug susceptibility studies on Microascus spp. by Sandoval-Denis et al (11) and Gao et al (16).…”

Section: Isolation Of M Cirrosus From the Patientmentioning

confidence: 94%

“…Curzi was reported to cause the first disseminated infection in a pediatric bone marrow transplant recipient in 1994 (12). Currently, there are a few species of M. cirrosus which have been publicly reported to cause human cutaneous and pulmonary infection (10,(12)(13)(14)(15)(16). The majority of these were determined by cultivation and morphological recognition.…”

Section: Microascus Cirrosus Sz 2021: a Potentially New Genotype Of M...mentioning

confidence: 99%

Microascus cirrosus SZ 2021: A potentially new genotype of Microascus cirrosus, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT

et al. 2023

View full text Add to dashboard Cite

Uncommon Microascus cirrosus (M. cirrosus) species have been reported to cause an increasing number of subcutaneous and invasive fungal infections worldwide; since the first human infection was reported in 1992, seven cases have been reported in PubMed. The present study reports a novel genotype named M. cirrosus SZ 2021 isolated from a patient undergoing hematopoietic stem cell transplantation, who exhibited extensive drug resistance and suffered a fatal pulmonary infection. This isolated M. cirrosus was cultured and determined by morphological observation, multi-locus sequence typing, matrix-assisted laser desorption and ionization time-of-flight mass spectrometry, and whole genome sequencing by next-generation sequencing. The whole nucleotide sequence (32.61 Mb) has been uploaded in the NCBI database (PRJNA835605). In addition, M. cirrosus SZ 2021 was not sensitive to the commonly used antifungal drugs, including fluconazole, amphotericin B, 5-flucytosine and caspofungin. The current literature on human infections by M. cirrosus was reviewed to closely define the comprehensive clinical characteristics and etiological identification. In brief, the present study identified a new M. cirrosus and summarized the clinical characteristics of fungal pneumonia by M. cirrosus species. Complete laboratory identification methods from morphology to gene sequencing were also established for an improved etiological identification and further investigation into the real prevalence of invasive pneumonia by M. cirrosus.

show abstract

“…A few species are also recognized as phytopathogens and opportunistic pathogens in insects and animals, including humans [142,143]. M. cirrosus causes cutaneous infection [144], pulmonary infection [145], and fatal invasive infection with fungemia [146]. There are cases of human subcutaneous infection caused by M. ennothomasiorum [147], mycetoma caused by M. gracilis [148], and suppurative cutaneous granulomata caused by M. cinereus [149].…”

Section: Fungi and Fungus-like Microorganisms (Oomycetes)mentioning

confidence: 99%

Microbial Pathogens in Aquaponics Potentially Hazardous for Human Health

Dinev,

Velichkova,

Stoyanova

et al. 2023

Microorganisms

View full text Add to dashboard Cite

The union of aquaculture and hydroponics is named aquaponics—a system where microorganisms, fish and plants coexist in a water environment. Bacteria are essential in processes which are fundamental for the functioning and equilibrium of aquaponic systems. Such processes are nitrification, extraction of various macro- and micronutrients from the feed leftovers and feces, etc. However, in aquaponics there are not only beneficial, but also potentially hazardous microorganisms of fish, human, and plant origin. It is important to establish the presence of human pathogens, their way of entering the aforementioned systems, and their control in order to assess the risk to human health when consuming plants and fish grown in aquaponics. Literature analysis shows that aquaponic bacteria and yeasts are mainly pathogenic to fish and humans but rarely to plants, while most of the molds are pathogenic to humans, plants, and fish. Since the various human pathogenic bacteria and fungi found in aquaponics enter the water when proper hygiene practices are not applied and followed, if these requirements are met, aquaponic systems are a good choice for growing healthy fish and plants safe for human consumption. However, many of the aquaponic pathogens are listed in the WHO list of drug-resistant bacteria for which new antibiotics are urgently needed, making disease control by antibiotics a real challenge. Because pathogen control by conventional physical methods, chemical methods, and antibiotic treatment is potentially harmful to humans, fish, plants, and beneficial microorganisms, a biological control with antagonistic microorganisms, phytotherapy, bacteriophage therapy, and nanomedicine are potential alternatives to these methods.

show abstract

Primary cutaneous infection due to Microascus cirrosus: a case report

Cited by 6 publications

References 5 publications

Pulmonary Microascus cirrosus infection in an immunocompetent patient with bronchiectasis: A case report

Pulmonary Microascus cirrosus infection in an immunocompetent patient with bronchiectasis: A case report

Microascus cirrosus SZ 2021: A potentially new genotype of Microascus cirrosus, which can cause fatal pulmonary infection in patients with acute leukemia following haplo‑HSCT

Microbial Pathogens in Aquaponics Potentially Hazardous for Human Health

Contact Info

Product

Resources

About