Pulmonary Microascus cirrosus infection in an immunocompetent patient with bronchiectasis: A case report

Liu, Qian; Kong, Luxia; Hua, Lijuan; Xu, Shuyun

doi:10.1016/j.rmcr.2021.101484

Cited by 5 publications

(3 citation statements)

References 17 publications

(23 reference statements)

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“…Twenty-two publications, mostly case reports and case series, gathering 100 patients have reported the use of n-AmB as an adjunctive treatment for IMIs (see Supplementary Materials, Table S1 ) [ 18 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Curative nebulized treatment has been used in two forms of aspergillosis, tracheobronchial (TBA) and invasive pulmonary aspergillosis (IPA), mainly in lung cancer patients or lung transplant recipients.…”

Section: Resultsmentioning

confidence: 99%

Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections

et al. 2022

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Pulmonary mold infections are life-threatening diseases with high morbi-mortalities. Treatment is based on systemic antifungal agents belonging to the families of polyenes (amphotericin B) and triazoles. Despite this treatment, mortality remains high and the doses of systemic antifungals cannot be increased as they often lead to toxicity. The pulmonary aerosolization of antifungal agents can theoretically increase their concentration at the infectious site, which could improve their efficacy while limiting their systemic exposure and toxicity. However, clinical experience is poor and thus inhaled agent utilization remains unclear in term of indications, drugs, and devices. This comprehensive literature review aims to describe the pharmacokinetic behavior and the efficacy of inhaled antifungal drugs as prophylaxes and curative treatments both in animal models and humans.

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Section: Resultsmentioning

confidence: 99%

Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections

et al. 2022

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“…A few species are also recognized as phytopathogens and opportunistic pathogens in insects and animals, including humans [142,143]. M. cirrosus causes cutaneous infection [144], pulmonary infection [145], and fatal invasive infection with fungemia [146]. There are cases of human subcutaneous infection caused by M. ennothomasiorum [147], mycetoma caused by M. gracilis [148], and suppurative cutaneous granulomata caused by M. cinereus [149].…”

Section: Fungi and Fungus-like Microorganisms (Oomycetes)mentioning

confidence: 99%

Microbial Pathogens in Aquaponics Potentially Hazardous for Human Health

Dinev,

Velichkova,

Stoyanova

et al. 2023

Microorganisms

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The union of aquaculture and hydroponics is named aquaponics—a system where microorganisms, fish and plants coexist in a water environment. Bacteria are essential in processes which are fundamental for the functioning and equilibrium of aquaponic systems. Such processes are nitrification, extraction of various macro- and micronutrients from the feed leftovers and feces, etc. However, in aquaponics there are not only beneficial, but also potentially hazardous microorganisms of fish, human, and plant origin. It is important to establish the presence of human pathogens, their way of entering the aforementioned systems, and their control in order to assess the risk to human health when consuming plants and fish grown in aquaponics. Literature analysis shows that aquaponic bacteria and yeasts are mainly pathogenic to fish and humans but rarely to plants, while most of the molds are pathogenic to humans, plants, and fish. Since the various human pathogenic bacteria and fungi found in aquaponics enter the water when proper hygiene practices are not applied and followed, if these requirements are met, aquaponic systems are a good choice for growing healthy fish and plants safe for human consumption. However, many of the aquaponic pathogens are listed in the WHO list of drug-resistant bacteria for which new antibiotics are urgently needed, making disease control by antibiotics a real challenge. Because pathogen control by conventional physical methods, chemical methods, and antibiotic treatment is potentially harmful to humans, fish, plants, and beneficial microorganisms, a biological control with antagonistic microorganisms, phytotherapy, bacteriophage therapy, and nanomedicine are potential alternatives to these methods.

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“…The family Microascaceae includes genera Microascus and Scopulariopsis , opportunistic fungi that have caused respiratory infection associated with poor outcome and an attributable mortality rate of 85%–100% ( 1 , 2 ). Treatment of invasive Microascus infection is challenging because of its high resistance to available therapies.…”

mentioning

confidence: 99%