PRIMARY CUTANEOUS IgA PLASMACYTOMA

Abstract

Clinical, laboratory and pathologic findings from a case of IgA (λ‐type) secreting extramedullary plasmacytoma of the skin are presented. The tumors were found first in the skin of the right upper extremity and then in the left maxillary sinus one year later. Materials were examined by peroxidase‐anti peroxidase method (PAP method) and the immunofluorescence method.

Primary cutaneous plasmacytoma in an HIV‐positive patient

“…6,13,21 Risk factors for a poor prognosis include multiple lesions, tumor size > 5 cm, IgA-secreting tumors, and a compromised immune system. 5,18,21 Tsuboi et al 22 found intralesional tumor necrosis factor-a reduced tumor size in a patient with multiple cutaneous plasmacytomas; however, lesion size did not change after the fourth injection. Oral cyclophosphamide and prednisolone were used subsequently, which reduced the tumor size and recurrence.…”

“…The average age of onset is 60.8 years (range: 16–88 years), and the male : female ratio is 4 : 1 . The prognosis is worse in patients presenting with multiple skin lesions, large lesion size, and immunoglobulin A (IgA)‐secreting tumors . Disease‐related mortality is at least 40%, and long‐term follow‐up indicates that more than half of patients relapse or progress to myelomatosis …”

“…4 The prognosis is worse in patients presenting with multiple skin lesions, large lesion size, and immunoglobulin A (IgA)-secreting tumors. 4,5 Disease-related mortality is at least 40%, and long-term follow-up indicates that more than half of patients relapse or progress to myelomatosis. 6 Clinical presentation varies significantly among patients.…”

“…These treatment modalities decrease lesion size, spread, and recurrence when they are used together or as single agents. 5,8,12,13,15,[17][18][19][20] Patients with multiple lesions or lesions that carry risk factors for recurrence can be treated with more aggressive options, such as chemotherapy. 6,13,21 Risk factors for a poor prognosis include multiple lesions, tumor size > 5 cm, IgA-secreting tumors, and a compromised immune system.…”

“…Surgical excision and local radiation are recommended for solitary lesions. These treatment modalities decrease lesion size, spread, and recurrence when they are used together or as single agents . Patients with multiple lesions or lesions that carry risk factors for recurrence can be treated with more aggressive options, such as chemotherapy .…”