Primary cutaneous plasmacytoma: Report of a case with review of the literature

Primary cutaneous plasmacytoma in an HIV‐positive patient

“…Characterization as a primary lesion requires the presentation of a neoplastic mass that is not metastatic from bone or soft tissue sites . The average age of onset is 60.8 years (range: 16–88 years), and the male : female ratio is 4 : 1 . The prognosis is worse in patients presenting with multiple skin lesions, large lesion size, and immunoglobulin A (IgA)‐secreting tumors .…”

“…The average age of onset is 60.8 years (range: 16–88 years), and the male : female ratio is 4 : 1 . The prognosis is worse in patients presenting with multiple skin lesions, large lesion size, and immunoglobulin A (IgA)‐secreting tumors . Disease‐related mortality is at least 40%, and long‐term follow‐up indicates that more than half of patients relapse or progress to myelomatosis …”

“…Polymerase chain reaction can be used to assess immunoglobulin heavy chain rearrangement to analyze a suspected monoclonal pattern. Failure to demonstrate a monoclonal rearrangement should not rule out a diagnosis of PCP . A complete workup should be conducted to rule out multiple myeloma and should include complete blood cell count, renal function, serum calcium level, urinalysis, Bence–Jones protein, radiographic studies to rule out lytic lesions, SPEP, and a negative bone marrow biopsy.…”

Primary cutaneous plasmacytoma: a role for a triggering stimulus?

“…Primary extramedullary plasmacytoma (PEP) is a collection of mature neoplastic plasma cells, without underlying multiple myeloma; PEP is usually solitary and arises outside the bone marrow. Sixty to 80% of cases of PEP arise in the upper digestive tract, whilst primary cutaneous plasmacytoma (PCP) is rare (2–4% of all PEPs) 1 . The mucosal localization of PCP, moreover, is rare with just four cases reported in the literature 2–5 .…”

Cutaneous Plasmacytosis

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] Cutaneous plasmacytosis was first described by Kimura et al 2 in 1983 in a patient with multiple cutaneous nodules and plaques associated with polyclonal hypergammaglobulinemia. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Cutaneous plasmacytosis was first described by Kimura et al 2 in 1983 in a patient with multiple cutaneous nodules and plaques associated with polyclonal hypergammaglobulinemia.…”