Primary cutaneous follicle center lymphoma of the arm with a novel chromosomal translocation t(12;21)(q13;q22): A case report

Jelić, Tomislav; Berry, Paula K.; Jubelirer, Steven; Plumley, Lisa; Hartel, Paul H; Estalilla, Oscar C; Chang, Hong‐Chan

doi:10.1002/ajh.20572

Cited by 8 publications

(2 citation statements)

References 20 publications

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“…Most cells had cleaved or irregular nuclei with dispersed chromatin or indistinct nucleoli, while the rest presented large round nuclei with prominent nucleoli ( figure 1D). Presentation on the arm has been described before, associated with arm swelling but with normal looking epidermis [4]. Immunohistochemical study revealed the following immunophenotype: CD45+, CD20+, CD79a+, PAX5+, CD10+, BCL6+, CD30++/-, MUM1-/+, CD45RA-/+, CD45RO-, CD3-, CD5-, CD23-, CCND1-, BCL2-, HLA-DR-/+, -, -(figures 1E-H).…”

Section: Primary Cutaneous Follicle Center Lymphoma Diffuse Type Wisupporting

confidence: 53%

Primary cutaneous follicle center lymphoma, diffuse type, with atypical clinical features

Κoletsa

Georgiou

Patsatsi

et al. 2014

European Journal of Dermatology

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249 not described. In our case, no rapid changes in size and color were observed in the remaining lesion on the glans over five subsequent years and, histologically, no malignant signs were found in the excised lesion. Therefore, we did not excise the lesion on the glans. Zembowicz et al. reported that sentinel lymph node metastasis may be found in up to 46% of cases of pigmented epithelioid melanocytoma, but favorable outcomes after 5year follow-up were described [8,10]. The lesion on our patient's glans is a pigmented epithelioid melanocytoma, namely, a borderline melanocytic tumor. Thus follow-up of this lesion without total excision is unprecedented and challenging, and considerable vigilance is required. Changes in dermoscopic findings should allow early detection of malignant change. We believe that the lesion was present at birth, according to embryogenetic hypothesis on divided nevus [2], but only became pigmented at the age of 8. In conclusion, pigmented epithelioid melanocytoma is a borderline melanocytic tumor with a low risk of local recurrence. Some cases without Carney complex have been reported [8], but the lesion is very rare in genital regions. Our unusual case involved a divided nevus on the penis. Diligent follow-up is necessary, not only of the lesion on the glans, but also the prepuce from which the tumor was removed.

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Section: Primary Cutaneous Follicle Center Lymphoma Diffuse Type Wisupporting

confidence: 53%

Primary cutaneous follicle center lymphoma, diffuse type, with atypical clinical features

Κoletsa

Georgiou

Patsatsi

et al. 2014

European Journal of Dermatology

View full text Add to dashboard Cite

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“…These signatures are different from the germinal center cell one observed in cutaneous cases of follicle center lymphoma, again pointing at different genetic backgrounds between cutaneous and nodal diseases. A t(12;21)(q13;q22) has been detected in one patient [38]. Gene expression studies using cDNA microarrays revealed that cases of cutaneous follicle center lymphoma have a germinal center cell signature [39,40] and show hypermutated immunoglobulin variable genes with frequent use of the VH1-69 and VH4-59 segments [41].…”

Section: Molecular Geneticsmentioning

confidence: 99%