Primary cutaneous adenoid cystic carcinoma on the lower leg

Takegawa, Masayasu; Kakudo, Natsuko; Morimoto, Naoki; Hihara, Masakatsu; Masuoka, Hiromu; Kusumoto, Kenji

doi:10.1093/jscr/rjz201

Cited by 4 publications

(4 citation statements)

References 6 publications

(7 reference statements)

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“…Reviewing the literature, only about 450 cases of PCACC have been reported [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ], with only two young patients (14 years of age) recorded [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

A Unique Case of Primary Cutaneous Adenoid Cystic Carcinoma Associated with Aplasia Cutis Congenita in a Four-Year-Old Female: A Case Report

et al. 2022

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Introduction: Primary cutaneous adenoid-cystic carcinoma (PCACC) is a rare malignant tumour reported in only about 450 cases in the literature, with only two adolescent cases reported. PCACC seems to occur between the fifth and seventh decade of life, and the most frequent regions involved are head and neck (46%). Aplasia cutis congenita (ACC) has an incidence of 1:10,000, and it seems to be rarely associated with neoplastic lesions. Interestingly, the association between PCACC and ACC has, so far, never been described. Methods: We report a case of PCACC in the scalp associated with ACC in a four-year-old patient. Discussion: The patient was under follow-up at the dermatology unit, but suddenly a red lesion appeared within the ACC. This red, ulcerated area increased rapidly over six months, so it was surgically removed, and the pathological examination results were suggestive for cribriform PCACC. According to the guidelines for skin tumours, the patient underwent widening resection, and an advancement-sliding skin flap was performed to recreate the scalp. After one year of follow-up, the patient has no local or widespread recurrence of the PCACC, and the surgical scar appears to have healed well. Conclusions: This clinical case is the first known patient with PCACC associated with ACC. A skin excision biopsy should be performed with wide margins to avoid a second widening resection of skin in a similar scenario. Genetic studies may help to identify the origin of this rare association.

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Section: Discussionmentioning

confidence: 99%

A Unique Case of Primary Cutaneous Adenoid Cystic Carcinoma Associated with Aplasia Cutis Congenita in a Four-Year-Old Female: A Case Report

et al. 2022

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“…2,4 Less often, it can be found on the trunk 6–8 or extremities. 9 Unlike ACC that can metastasize to lungs, bones and soft tissues, PCACC rarely metastasizes 10 but can display local perineural involvement with a tendency to reoccur locally. 11 As PCACC might resemble micronodular basal cell carcinoma (BCC) on histopathology, distinctive features help to rule out other differentials.…”

Section: Discussionmentioning

confidence: 99%

Rare case of primary cutaneous adenoid cystic carcinoma of the abdomen: A case report

Chivinski

Watters

Mereniuk

2022

SAGE Open Medical Case Reports

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Adenoid cystic carcinoma is predominantly a tumor of the parotid glands and can sometimes be found in other glands. In most cases, skin location is usually a metastatic presentation and rarely a primary tumor. We describe the case of a 59-year-old female patient presenting with a 5-mm skin-colored nodule on the abdomen histologically compatible with a primary cutaneous adenoid cystic carcinoma. Extensive workup revealed no other primary source, nor evidence of metastatic disease; therefore, wide local excision was the preferred treatment given the low potential of recurrence. As this adnexal carcinoma is rare and its morphology non-specific clinically, we wanted to raise awareness of this entity and its management.

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“…Primary cutaneous adenoid cystic carcinoma (PCAdCC) is a rare entity, with only 131 cases previously reported in the English literature, after exclusion of cases occurring in the periocular region and ear canal 1‐8 . As compared to its counterpart in salivary gland, it tends to follow a more indolent course, often with multiple recurrences 9,10 .…”

Section: Figurementioning

confidence: 99%

“…Histopathology of primary cutaneous adenoid cystic carcinoma of the scrotum presenting with predominantly solid growth Sarah E. Gradecki MD 1 | Alejandro A. Gru MD 1 | Kerri E. Rieger MD PhD 2 | Shyam S. Raghavan MD 1 Primary cutaneous adenoid cystic carcinoma (PCAdCC) is a rare entity, with only 131 cases previously reported in the English literature, after exclusion of cases occurring in the periocular region and ear canal. [1][2][3][4][5][6][7][8] As compared to its counterpart in salivary gland, it tends to follow a more indolent course, often with multiple recurrences. 9,10 The majority of PCAdCCs are found in the head and neck region or trunk.…”

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confidence: 99%

Histopathology of primary cutaneous adenoid cystic carcinoma of the scrotum presenting with predominantly solid growth

et al. 2020

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Primary cutaneous adenoid cystic carcinoma on the lower leg

Cited by 4 publications

References 6 publications

A Unique Case of Primary Cutaneous Adenoid Cystic Carcinoma Associated with Aplasia Cutis Congenita in a Four-Year-Old Female: A Case Report

A Unique Case of Primary Cutaneous Adenoid Cystic Carcinoma Associated with Aplasia Cutis Congenita in a Four-Year-Old Female: A Case Report

Rare case of primary cutaneous adenoid cystic carcinoma of the abdomen: A case report

Histopathology of primary cutaneous adenoid cystic carcinoma of the scrotum presenting with predominantly solid growth

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