Rare case of primary cutaneous adenoid cystic carcinoma of the abdomen: A case report

Abstract

Adenoid cystic carcinoma is predominantly a tumor of the parotid glands and can sometimes be found in other glands. In most cases, skin location is usually a metastatic presentation and rarely a primary tumor. We describe the case of a 59-year-old female patient presenting with a 5-mm skin-colored nodule on the abdomen histologically compatible with a primary cutaneous adenoid cystic carcinoma. Extensive workup revealed no other primary source, nor evidence of metastatic disease; therefore, wide local excision was the preferred treatment given the low potential of recurrence. As this adnexal carcinoma is rare and its morphology non-specific clinically, we wanted to raise awareness of this entity and its management.

Primary Cutaneous Adenoid Cystic Carcinoma of the Back: A Case Report

“…Additionally, various histopathological markers are indicative of this tumor type. Specifically, mucin secretion is typically observed, along with two distinct cell populations: ductal and myoepithelial [ 14 ]. These cell types are positive for CD117 and S100, respectively.…”

“…These markers are crucial as they are not present in other types of cutaneous carcinomas, such as adenoid basal cell carcinoma. This underscores the importance of cytological pathology and immunohistochemistry in guiding the diagnosis and treatment of such tumors [ 14 ].…”

“…Although metastasis of PCACC is rare, perineural involvement increases the tendency for local recurrence, which occurs 76% of the time [13]. Assessing the extent of perineural invasion proves to be difficult, which is why prompt adjuvant therapy or sentinel lymph node biopsies are often indicated [14][15][16]. The use of postoperative chemotherapeutic agents or radiation is controversial, with conflicting opinions among experts.…”