Primary cultures of cardiac muscle cells as models for investigation of protein glycosylation

Henning, Ursula; Wolf, Wolf-Peter; Holtzhauer, Martin

doi:10.1007/978-1-4613-1279-6_5

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…In the in vitro preparation, the decline in myocardial tension observed with Lzm-S occurs within 5 mins, and thus its mechanism of action would favor a direct effect on the myocardium (12,22). In the heart, most membrane proteins are posttranslationally modified, are heavily N-glycosylated, and therefore are glycoproteins (23)(24)(25)(26). Others have found that changes in Nglycosylation may alter the function of L-type calcium channels, regulation of potassium channels, and activation of sodium channels (24 -26).…”

Section: Discussionmentioning

confidence: 98%

N,N′,N′-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs*

Mink

Jacobs

Duke

et al. 2004

Critical Care Medicine

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Section: Discussionmentioning

confidence: 98%

N,N′,N′-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs*

Mink

Jacobs

Duke

et al. 2004

Critical Care Medicine

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“…The function of these carbohydrates has not yet been well examined. However, the α1-subunit of the Ca 2+ channel lacks extensive glycosylation Henning et al 1996), which suggests that the critical functions of the channel can be fulfilled without direct participation of carbohydrates. It is known that glycosylation is an essential process in the maintenance of the normal steady state of biosynthesis and degradation of sodium channels (Waechter et al 1983).…”

Section: Glycosylation Of Vgscsmentioning

confidence: 99%

Structure, function and pharmacology of voltage-gated sodium channels

Denac¹,

Mevissen²,

Scholtysik³

2000

Naunyn-Schmiedeberg's Archives of Pharmacology

142

108

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Voltage-gated sodium channels (VGSCs) are responsible for the initial inwards current during the depolarisation phase of action potential in excitable cells. Therefore, VGSCs are crucial for cardiac and nerve function, since the action potential of nerves and muscle cannot occur without them. Their importance in generation and transmission of signals has been known for more than 40 years but the more recent introduction of new electrophysiological methods and application of molecular biology techniques has led to an explosion of research on many different ion channels, including VGSCs. Their extraordinary biological importance makes them logical and obvious targets for toxins produced by animals and plants for attack or defence. The action of these and similar substances modulating the function of the VGSCs is interesting with respect to their possible use in medicine or use as tools in the study of these molecules. This review summarises recent progress in this research field and, in particular, considers what is known about the relationship of the structure to function, including a current understanding of the pharmacological modulation of VGSCs.

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Primary cultures of cardiac muscle cells as models for investigation of protein glycosylation

Cited by 2 publications

References 17 publications

N,N′,N′-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs*

N,N′,N′-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs*

Structure, function and pharmacology of voltage-gated sodium channels

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