Primary Crohn's disease of the colon and rectum

Granulomatous ileocolitis

“…It is not uncommon for a specimen to show some but not all the pathological features of the granulomatous process. At times, especially when ulceration is severe, granulomas may be difficult to find, and experienced pathologists may make a diagnosis of granulomatous disease in the absence of granulomas (Comes and Stecher, 1961), provided other features are present.…”

“…Granulomatous ileocolitis differs from regional ileitis and from granulomatous colitis only in its anatomical distribution. British authors (Lockhart-Mummery and Morson, 1960;Comes and Stecher, 1961) use the term 'Crohn's disease' to describe this entity wherever it occurs in the gut, but contributors to the American literature tend to avoid eponyms. We have preferred the term 'granulomatous' to avoid confusing this process with the segmental (right-sided) colitis described by Crohn and considered by him to be ulcerative.…”

An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area.

“…Lockhart-Mummery and Morson (1960) found that cases of Crohn's disease of the colon typically present with diarrhoea, rectal bleeding being unusual except when the rectum is involved. Cornes and Stecher (1961) have suggested that the incidence of primary Crohn's disease of the colon is higher in old age than that of ulcerative colitis. Their evidence, however, was based on surgical resection specimens from an undefined population.…”

Joint Manifestations in Gastrointestinal Diseases

“…the ob servation that CD without colonic involve ment has a reduced incidence of peripheral arthritis may support the notion that the dis tal part of the bowel plays a critical role in the development of joint manifestations [12,146]. In one study [90] of 45 patients with CD of the large intestine, a rather high prevalence (15.5%) of peripheral arthritis was observed. On the other hand, none of 6 patients with ankylosing spondylitis and CD had colonic involvement [148], Some uncertainty exists regarding the pos sible association between the occurrence of arthritis in CD and other major complica tions of this disease such as fistula formation and malabsorption [21], On the other hand, an association between development of ery thema nodosum and arthritis seems to exist [98] in CD as it does in UC.…”

“…The prevalence of arthritis of the peripheral joints among patients afflicted by CD varies from 0.4 to 23.0% [90,[135][136][137][138][139][140][141][142][143][144][145][146] (table 7). The peripheral arthritis of this IBD resembles that of UC [21 ] and is characterized by subacute episodes in volving a few joints [146] in an asymmetric distribution.…”