Primary Colorectal Lymphoma—Clinical Outcomes in a Population-Based Series

Drolet, Sébastien; MacLean, Anthony R.; Stewart, Douglas A.; Dixon, Elijah; Paolucci, Elizabeth Oddone; Buie, W. Donald

doi:10.1007/s11605-011-1572-0

Cited by 20 publications

(14 citation statements)

References 31 publications

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“…Approximately 41.8% and 21.3% of PCL patients were in Ann Arbor stages IE and IVE, respectively, which is similar to the results from a German multicenter trial [27]. Consistent with published reports [8, 10, 11, 16, 20], the most frequent tumor location was the cecum (34.9%), which primarily results from the abundance of lymphoid tissues in the lesion. The most common histological subtype in the present study was diffuse large B-cell (41.6%), and the proportion of T-cell lineage from the present results was lower than 17.9%, which was reported previously by the Korean Association for the Study of Intestinal Diseases [12].…”

Section: Discussionsupporting

confidence: 87%

“…This finding was corroborated by evidence from Droletet al [11]. Early tumor stage and indolent lymphoma, which are good prognostic factors of survival in primary gastrointestinal lymphoma[7], were also associated with improved survival in PCL.…”

Section: Discussionsupporting

confidence: 63%

“…PCL is a rare colorectal neoplasm with a gradually increasing incidence [9, 11, 17]. Previous studies that investigated the epidemiological features and survival of PCL were predominantly based on populations from a single institution and case reports; these studies only involved 7-95 patients [8, 10–13, 16, 18–26].…”

Section: Discussionmentioning

confidence: 99%

“…Abdominal pain is perceived as the most common symptom. Changes in bowel habits and bloody stools are also frequently encountered [11, 12]. It is difficult to differentiate PCL from typical digestive diseases in adults because of these non-specific clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

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The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis

Cai

Chen

et al. 2016

Oncotarget

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BackgroundPrimary colorectal lymphoma (PCL) is a rare colorectal malignancy. The standard treatment and prognostic factors of PCL remain unexplored. Therefore, a large population-based study should be conducted to provide a detailed review of this disease.MethodsWe extracted the data of eligible patients with PCL registered in the SEER database from 1973 to 2011. All statistical analyses were performed using SPSS 19.0.ResultsA total of 2050 (61.3%) of the 3342 patients with PCL underwent surgical intervention, and 1292 (38.7%) patients received no surgical treatment. The median overall survival was 95 months, and patients receiving surgery exhibited significantly prolonged survival (adjusted HR =0.69, P <0.001). Young age, early tumor stage, and indolent lymphoma were independent predictors of improved survival. Further survival analyses demonstrated the potential benefit of surgery in patients with early tumor stage, right-sided lesions, or diffuse large B-cell PCL. Conversely, surgical intervention did not improve the survival of patients with advanced-stage, left-sided, or indolent PCL.ConclusionPCL is a rare tumor that can be effectively treated. Surgical intervention may play an important role in the treatment of PCL. Early tumor stage, a right-sided lesion, and diffuse large B-cell histological PCL seem to be the clinical characteristics of optimal surgical candidates.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis

Cai

Chen

et al. 2016

Oncotarget

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“…Les facteurs de bon pronostic sont l'âge jeune et le traitement chirurgical. La localisation rectale constitue un facteur de mauvais pronostic [10]. Notre observation illustre le mauvais pronostic de ce type de lymphome colique malgré une prise en charge « adé-quate » et rapide.…”

Section: Discussionunclassified

Lymphome diffus à grandes cellules B primitif du côlon transverse

Mnif¹,

Medhioub²,

Amouri³

et al. 2012

Acta Endosc

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La localisation rectocolique des lymphomes non hodgkiniens primitifs extranodaux demeure rare et ne repré-sente que 10-20 % des lymphomes gastro-intestinaux et 0,2-0,6 % des tumeurs malignes colorectales. Nous rapportons l'observation d'un homme âgé de 84 ans qui était hospitalisé pour exploration d'une constipation avec douleur abdominale. La coloscopie avait montré une lésion ulcérée du côlon transverse dont les biopsies avaient conclu à un lymphome B à grandes cellules. Le bilan d'extension était négatif. Le patient est décédé après trois cures de chimiothérapie. À travers cette observation et une revue de la litté-rature, nous discuterons les caractéristiques épidémio-logiques, clinicomorphologiques et thérapeutiques de cette entité rare. Pour citer cette revue : Acta Endosc. 42 (2012). Mots clés Lymphome non hodgkinien · Lymphome extranodal · Côlon · ChimiothérapieAbstract Rectocolonic localization of primitive extranodal non-Hodgkin lymphoma remains rare. It accounts for only 10-20% of gastrointestinal lymphomas and 0.2-0.6% of colorectal malignancies. We report the case of a patient aged 84 years who was admitted for exploration of constipation with abdominal pain. Colonoscopy revealed an ulcerated lesion of the transverse colon. Histological examination revealed a diffuse large B-cell lymphoma. The staging was negative. The patient died after three cycles of chemotherapy. Through this observation and the literature review, we discuss the epidemiological and clinical-morphological features and treatment of this rare entity. To cite this journal: Acta Endosc. 42 (2012).

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