Primary Clear Cell Carcinoma of the Liver with Intracerebral Hemorrhage as First Presentation: Case Report

Zhou, Haiyang; Lv, Liquan; Ding, Xuehua

doi:10.1159/000323383

Cited by 1 publication

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“…It is noteworthy that patients with liver cancer can also develop complications of cerebral hemorrhage [ 3 , 13 – 16 ] or hematomas [ 17 ]. On some occasions, intracerebral hemorrhage is the first presentation of brain metastatic primary clear cell carcinoma of the liver [ 18 , 19 ]. However, to date, no study has reported clinical features and potential pathogeneses of liver cancer accompanied by cerebral hemorrhage as a complication.…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Liver Cancer with Cerebral Hemorrhage

Chen

Huang

et al. 2016

Med Sci Monit

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BackgroundCerebral hemorrhage is common in patients with cancer, but the clinical features and pathogenesis of liver cancer patients with cerebral hemorrhage are not well known.Material/MethodsLiver cancer patients who developed cerebral hemorrhage were recruited from the First Affiliated Hospital of Guangxi Medical University between January 2003 and December 2014. We retrospectively analyzed clinical presentations, results of laboratory tests, and imaging examinations. The clinical features and pathogenesis were summarized.ResultsAmong 11133 patients with liver cancer, 9 patients (0.08%), including 3 females and 6 males met the inclusion criteria. The age range was 48–73 years and the average age was 61.67±8.97 years. Five patients did not have traditional hemorrhage risk factors and 4s had the risk factors; however, all had developed hepatocellular carcinoma, and 3 had developed metastasis. All 9 patients showed elevated tumor markers: an increased AFP level was detected in 6 patients, coagulation dysfunctions in 8 patients, and abnormal liver functions in 6 patients. Five patients had developed cerebral hemorrhagic lesions in the lobes of their brains, while hemorrhagic lesions in the basal ganglia occurred in 3 patients and in the brainstem in only 1 patient. Four patients had clear consciousness, while 5 patients were in coma and showed poor prognosis.ConclusionsPatients who have liver cancer complicated with cerebral hemorrhage usually lack traditional risk factors of cerebral hemorrhage. The site of cerebral hemorrhage is often detected in the lobes of the brain. Coagulation dysfunctions might be the main pathogenesis of liver cancer complicated with cerebral hemorrhage.

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