Clinical Features of Liver Cancer with Cerebral Hemorrhage

Lu, Qiuhong; Chen, Li; Huang, Guifeng; Qin, Chao; Cheng, Daobin; Yu, Lixia; Liang, Zhijian

doi:10.12659/msm.898642

Cited by 4 publications

(2 citation statements)

References 31 publications

(32 reference statements)

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“…Previous studies found that the elevated plasma cancer markers (CA125, CA153, CA199, CEA, and alpha-fetoprotein) may associate with cerebral hemorrhage patients with cancer. [15,36] In present study, it was found that elevated plasma CEA and CA199 levels were the independent risks for cerebral hemorrhage in patients with active LC. Although it was still unclear, it was interesting that the elevated CEA and CA199 levels play what a role in the pathogenesis of LCRCH.…”

Section: Discussionsupporting

confidence: 51%

The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage

et al. 2019

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Cerebral hemorrhage is one of the common complications in patients with lung cancer (LC). Although cancer related cerebral hemorrhage was aware, the pathogenesis and biomarkers of lung cancer related cerebral hemorrhage (LCRCH) remained not well known. The aim of this study was to investigate the pathogenesis and plasma biomarkers of LCRCH. A retrospective review was conducted on acute cerebral hemorrhage patients with active LC who was admitted to the hospital between January 2007 and December 2017. A total of 56 patients with LCRCH (active LC patients with acute cerebral hemorrhage but without conventional vascular risks) was recruited. Meanwhile, 112 patients with active LC alone and gender, age, and subtype of cancer cell matched were recruited as control group. In LCRCH patients, most of the hemorrhagic lesions were located in lobes. And most of them with adenocarcinoma were in medium to terminal stage with poor prognosis short-term. Moreover, LCRCH patients had a lengthened prothrombin time (PT), elevated plasma carcinoembryonic antigen (CEA), cancer antigen 125 (CA125) and cancer antigen 199 (CA199) levels and decreased platelet (PLT) level than did the patients with LC. Multivariate logistic regression analysis showed that lengthened PT, elevated plasm CEA, and CA199 levels were independent risk factors for LCRCH. It was suggested that lengthened PT, elevated plasm CEA and CA199 levels associated with the pathogenesis of LCRCH, and that the Index derived from independent risks should be serve as a specific biomarker of LCRCH.

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Section: Discussionsupporting

confidence: 51%

The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage

et al. 2019

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“…During radiotherapy, there is a risk of damaging the blood vessels around the tumors, which easily causes hemorrhage after radiotherapy (26). Clinically, the common ones are hemorrhages after radiotherapy for cervical cancer, bladder cancer, nasopharyngeal cancer and esophageal cancer (27)(28)(29)(30).…”

Section: Hemorrhage After Radiotherapymentioning

confidence: 99%

Clinical application of interventional embolization in tumor-associated hemorrhage

Chen¹,

Yang

Xu³

et al. 2020

Ann Transl Med

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Recently, the main clinical treatment methods for tumor-associated hemorrhage include systemic therapy, the application of hemostatic drugs, blood transfusion, symptomatic support therapy and endoscopic interventional hemostasis. Endoscopic hemostasis is performed mainly for patients with gastrointestinal bleeding, and the procedures include hardening of the blood vessels and the injection of hemostatic drugs.Surgical hemostasis methods mainly include the surgical ligation of bleeding blood vessels or tumor resection for hemostasis. Interventional hemostasis is a new hemostasis method. With the development of interventional radiology in recent years, transcatheter arterial embolization (TAE) can quickly detect and accurately embolize arterial blood vessels. It is the preferred treatment for present tumor-associated hemorrhages.

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Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage

et al. 2018

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BackgroundThis study aimed to investigate the potential neuroprotective effect of recombinant osteopontin (r-OPN) on apoptotic changes via modulating phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK-3β) signaling in a rat model of intracerebral hemorrhage (ICH).Material/MethodsWe subjected 10–12-week-old Sprague-Dawley male rats (n=120) to injection of autologous blood into the right basal ganglia to induce ICH or sham surgery. ICH animals received vehicle administration, r-OPN (4 μL/pup), or r-OPN combined with phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin (86 ng/pup) at 30 min after injury. Neurological scores and rotarod latencies were evaluated on days 1–5 post-ICH. Brain water content was evaluated on days 1–3 post-ICH. The number of apoptotic cells changes were evaluated by terminal deoxynucleotidyl transferase-mediated 2-deoxyuridine 5-triphosphate-biotin nick-end labeling (TUNEL) and hematoxylin staining. Apoptosis-related proteins Bcl-2, Bax, and cleaved caspase-3 (CC3), and the phosphorylation levels of Akt and GSK-3β were assayed by Western blot.ResultsNeurological deficits, rotarod latencies, and brain water content following ICH were reduced in the r-OPN group compared to the vehicle group. r-OPN also attenuated cell death in ICH. Furthermore, treatment with r-OPN significantly increased p-Akt expression and decreased p-GSK-3β. These effects were associated with a decrease in the Bax/Bcl-2 ratio and the suppression of CC3 at 24 h after ICH. Importantly, all the beneficial effects of r-OPN in ICH were abrogated by the PI3K inhibitor wortmannin.Conclusionsr-OPN may provide a wide range of neuroprotection by suppressing apoptosis through the PI3K/Akt/GSK-3β signaling pathway after ICH.

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Clinical Features of Liver Cancer with Cerebral Hemorrhage

Cited by 4 publications

References 31 publications

The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage

The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage

Clinical application of interventional embolization in tumor-associated hemorrhage

Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage

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