Primary Choriocarcinoma of the Uterine Cervix: Clinical, MRI, and Color Doppler Ultrasonographic Study

Yahata, Tetsuro; Kudoh, Shoji; Kase, Hiroaki; Sekizuka, Naoto; Kurabayashi, Takumi; Aoki, Yoichi; Tanaka, Kenichi

doi:10.1006/gyno.1996.4541

Cited by 24 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The HFUS technique has already been used to determine the malignancy of carcinomas. [15][16][17][18][19][20] The necrosis detected with ultrasound is seldom used as a prognostic predictor for treatment efficacy. As an example, in 1997 Kenji et al showed that it could be a relevant tool for determining the efficacy of molecules, such as Lipiocis (CIS Bio-International, Gif-sur-Yvette, France) in the treatment of hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

et al. 2006

View full text Add to dashboard Cite

Tumor growth is dependent both on endothelial and tumor cells. The aim of this study was to investigate dynamically whether changes in tumor vasculature implicate tumor tissue degeneration during antiangiogenic therapies. In order to quantify intra-tumor vascularization and necrosis, we have used ultrasound technology. This study has identified essential parameters needed to quantify specifically and sensitively the number of microvessels and the extent of necrosis in xenografted human carcinomas during natural tumor evolution, using contrast-enhanced high-frequency ultrasonography with (HFCDUS) or without (HFUS) color Doppler. We showed that quantification of intra-tumor microvessels between HFCDUS and immunohistochemistry is correlated using an anti-CD31 antibody. Furthermore, quantification of tumor necrosis with HFUS was confirmed by histological examination of hematoxylin-eosin-saffraninstained sections over the observation period. Subsequently, for the assessment of novel angiogenic inhibitors, HFCDUS and HFUS were used to elucidate the underlying dynamics linking vessel inhibition and tumor eradication. We describe a novel application for HFCDUS/HFUS that constitutes an effective, convenient, and non-invasive method for clinical assessment of angiogenic inhibitors. In conclusion, we showed that tumor cells abruptly became necrotic following an antivascular therapy, whereas untreated tumors were protected from degeneration by a significant blood supply.

show abstract

Section: Introductionmentioning

confidence: 99%

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

et al. 2006

View full text Add to dashboard Cite

show abstract

“…However, the overall incidence of choriocarcinoma in recent years has been decreased parallel to improving socioeconomic conditions [13]. Primary choriocarcinoma of the cervix is an extremely rare disease; however, most of the case reports in literatures demonstrate that extrauterine choriocarcinoma mostly originates in cervix rather than other sites in genital tract [2][3][4][5][6][7]. Our case fulfilled the criteria defined by Saito et al [1].…”

Section: Discussionmentioning

confidence: 64%

“…The predominant symptom is abnormal vaginal bleeding which is due to angiogenesis and neovasculirization of this tumor. There are few differential diagnoses which include uterine cervical pregnancy, threatened abortion, a cervical polyp and malignancy [4]. In the present case, choriocarcinoma was presented with vaginal bleeding and misdiagnosed as malignancy.…”

Section: Discussionmentioning

confidence: 67%

“…As we mentioned above, in cervical lesions in women of child-bearing age with profuse bleeding, measurement of serum and urinary B-hCG is useful for diagnosis. Color Doppler transvaginal ultrasonography and MRI with contrast detect the abundant blood flow in the tumor [4]. Transvaginal Doppler sonography allows detection of tumoral vessels, which manifests high diastolic blood flow and low impedance resulting in neovasculirization [4].…”

Section: Discussionmentioning

confidence: 99%

“…Saito et al defined following diagnostic criteria for extrauterine choriocarcinoma in 1965: 1) absence of disease in the uterine cavity, 2) exclusion of coexistence of normal intrauterine pregnancy, 3) exclusion of molar pregnancy and 4) pathologic confirmation of disease [1]. Most of the extrauterine choriocarcinoma reported in literature, originates in uterine cervix [2][3][4][5][6][7]. However, there are also reports in the literature that choriocarcinoma located in other regions outside the uterus in genital tract such as ovary [8], tube [9], vulva [10] and vagina [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

Behtash¹,

Zarchi²,

Shamshirsaz³

et al. 2013

JCT

View full text Add to dashboard Cite

Background: Primary choriocarcinoma of the cervix is a very rare entity. Case: A 35-year-old patient had been admitted to our hospital with vaginal bleeding for 7 months. A cervical mass measured 4 × 4 cm was palpated on the anterior surface of the cervix. Biopsy of the lesion demonstrated extensive necrosis and was in favor of squamous cell carcinoma. Patient was accepted as FIGO stage I b1-2 and underwent type II hysterectomy with bilateral salpingoopherectomy and bilateral pelvic lymph node dissection was carried out. Post operative pathologic evaluation of the surgical specimen evinced that the case was primary cervical choriocarcinoma. Conclusion: Primary choriocarcinoma of the cervix should be considered in patients in their reproductive years with cervical lesion and negative cervical cytology. Beta-hCG assay and transvaginal color Doppler sonography are useful for early diagnosis.

show abstract

Primary choriocarcinoma of uterine cervix treated by uterine artery drug pouring and embolism: one case report

Wang

Jiang

Wang

et al. 2009

Chin. -Ger. J. Clin. Oncol.

View full text Add to dashboard Cite

Primary choriocarcinoma of the uterine cervix (PCC) is an extremely rare disease. The conventional treatment of PCC is a combination of hysterectomy and chemotherapy. We present one rare case proved by cervical biopsy. The patient was an 36-year-old Chinese woman with irregular vaginal bleeding for 60 days. A cervical tumoral mass was seen in the pelvic examination and biopsy revealed active hyperplasia of trophoblastic cell. Because of massive vaginal haemorrhage, the patient accepted uterine artery drug pouring and embolism emergently. This management had gained a satisfactory effect. Thus, Uterine artery drug pouring and embolism is one new and effective weapon for PCC, which can preserve the patient's productive ability.

show abstract

Primary Choriocarcinoma of the Uterine Cervix: Clinical, MRI, and Color Doppler Ultrasonographic Study

Cited by 24 publications

References 0 publications

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

Primary choriocarcinoma of uterine cervix treated by uterine artery drug pouring and embolism: one case report

Contact Info

Product

Resources

About