Primary Choriocarcinoma of the Lung:<i>Presentation of a Case and Review of the Literature</i>

Zapatero, J.; Bellon, Jennifer R.; Baamonde, C.; Aragoneses, Federico González; Cubillo, José Manuel; Orusco, Eduardo Delgado; Gallardo, M. Perez; Domínguez, J. Zapatero; Folqué, E.

doi:10.3109/14017438209101063

Cited by 26 publications

(14 citation statements)

References 3 publications

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“…The pathogenesis of primary pulmonary choriocarcinoma remains controversial; choriocarcinoma may occur from pulmonary epithelium either of neoplastic or non‐neoplastic, 25,26 , 32,35 , 36 retained primordial germ cells that have abnormally migrated during embryonic development, 20,22 , 37 or pulmonary embolism by trophoblastic tissue related to the gestational events 24,30 , 33 . In the present case, dedifferentiated carcinomatous cells found near the choriocarcinomatous areas were positive for β‐hCG and PLAP.…”

Section: Discussionmentioning

confidence: 52%

“…Most cases arise in the midline structures with male predominance, and often coexist with other germ‐cell tumor components 1,2 . However, non‐gestational choriocarcinoma infrequently involves non‐midline lesions with no other germ‐cell tumor components 3–46 . Primary pulmonary choriocarcinoma is an extremely rare neoplasm representing such tumors 17–39 .…”

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confidence: 99%

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Primary pulmonary choriocarcinoma combined with adenocarcinoma

Yamamoto¹,

Tanaka

Takeo³

et al. 2006

Pathology International

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An extremely rare autopsy case of primary pulmonary choriocarcinoma combined with adenocarcinomatous components in a 77-year-old Japanese man is described. The patient died of rapidly progressive respiratory dysfunction without ante-mortem diagnosis. Autopsy revealed necro-hemorrhagic areas of the primary lung tumor with a typical biphasic pattern of choriocarcinoma. Topographical analysis suggested that moderately to poorly differentiated adenocarcinoma components partially surrounded the choriocarcinomatous components. Moreover, dedifferentiated carcinomatous components were scattered next to both adenocarcinomatous and choriocarcinomatous areas, and a few cells of the dedifferentiated carcinomatous components had a similar immunoreaction to conventional adenocarcinomatous or choriocarcinomatous components, such as surfactant apoprotein A, placental alkaline phosphatase or beta-human chorionic gonadotropin. Additionally, epithelial membrane antigen-positive cytotrophoblastic cells were rarely found in choriocarcinomatous areas. The present case suggests that primary lung choriocarcinoma can occur closely related to conventional pulmonary adenocarcinoma, although collision tumor was not completely ruled out.

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Section: Discussionmentioning

confidence: 52%

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confidence: 99%

Primary pulmonary choriocarcinoma combined with adenocarcinoma

Yamamoto¹,

Tanaka

Takeo³

et al. 2006

Pathology International

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“…A few cases of lung cancer producing hCG with hormonal symptoms, such as gynecomastia in a man and genital bleeding in a female patient, have been reported 15,30–35 . However, most of the patients reported did not have hormonal symptoms 13,21,22,24,26,27,31,36,37 . Such symptoms are induced by a remarkable elevation in serum hCG.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary pleomorphic carcinoma producing hCG

Honda¹,

Yoshida²,

Sakamoto³

et al. 2007

Pathology International

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An 80-year-old woman with a pleomorphic carcinoma (PC) producing hCG was admitted to Nippon Steel Hirohata Hospital because of an abnormal shadow on CT seen during a follow-up examination after surgery for breast cancer. A right upper lobectomy was performed due to rapid growth of the shadow 3 months later. Macroscopically the tumor was a 4.8 x 4.0 cm well-circumscribed grayish-white mass. On histology the tumor consisted mostly of intermingled spindle and polygonal cells, while evidence of poorly differentiated adenocarcinoma was seen in a few areas. A diagnosis of PC was made due to hCG expression in approximately 20% of the spindle and polygonal cells on immunohistology. Six months after the operation metastasis to the liver and adrenal gland was seen on CT. The patient died due to metastases 1 year after the operation, even though the patient had been at stage 1B at the time of the operation and appropriate chemotherapy had been given. PC patients with immunohistochemical hCG expression have elevated risk of local recurrence and metastasis.

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“…Because of the rarity and the clinicopathological similarity of PCC and hCG-producing GCC, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][25][26][27][28][29][30][31][32] the criteria for distinguishing them are unclear. Thus, differential diagnosis has been very difficult.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, small-cell carcinoma of the lung often induces paraneoplastic syndromes by producing hormonal factors. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] A diagnosis of PCC should be made carefully. Human chorionic gonadotrophin (hCG) is one of the most common hormones produced by pulmonary carcinomas, 1-3 but clinical findings and problems associated with the hormone are not so frequent.…”

Section: Introductionmentioning

confidence: 99%