Primary cholesterol hepatolithiasis: A disease with a different pathogenesis

Anatomic hepatectomy as a definitive treatment for hepatolithiasis: a cohort study

“…In the present study, an analysis of causes associated with hepatolithiasis revealed that 50.0% of patients showed evidence of Caroli's disease in biopsy specimens. Similar results have been reported by other authors in occidental countries, 19,33 where patients have a different pathophysiology 34 …”

Apolipoprotein AI‐CIII‐AIV gene cluster polymorphisms in relation to cholesterol gallstone

“…Cholesterol gallstone is a disease with multiple causes. The decreased level of high density lipoprotein cholesterol (HDL‐ch) and increased levels of very low density lipoprotein cholesterol (VLDL‐ch) and triglyceride (TG) in plasma cause the increase of cholesterol, the decrease of bile acid and phospholipid content in the bile, thus leading the cholesterol in a hypersaturated state and easily precipitated crystal nucleation which are the precondition of the formation of cholesterol gallstones 1–6 …”

“…The decreased level of high density lipoprotein cholesterol (HDL-ch) and increased levels of very low density lipoprotein cholesterol (VLDL-ch) and triglyceride (TG) in plasma cause the increase of cholesterol, the decrease of bile acid and phospholipid content in the bile, thus leading the cholesterol in a hypersaturated state and easily precipitated crystal nucleation which are the precondition of the formation of cholesterol gallstones. [1][2][3][4][5][6] A disorder of the lipid metabolism is mainly caused by the abnormality of apoprotein (Apo) metabolism which is affected by the polymorphism of apoprotein. ApoAI is a primary apoprotein which plays an important role in lipid transportation, and the formation and activity of ApoAI is closely related to the formation of cholesterol gallstones.…”

“…It was found that the content of ApoCIII in patients with cholesterol gallstones was positively correlated with the content of cholesterol in bile and/or the cholesterol saturation index. 2 In this article we report our study of the relation between the polymorphism of the ApoAI-CIII-AIV gene cluster and cholesterol gallstones by a case-control study, which may provide a hint for investigating molecular pathogenetics and the genetic susceptible factors of cholesterol gallstones.…”