Primary cerebral angiosarcoma

Charman, Howard P.; Lowenstein, Daniel H.; Cho, Kyung G.; DeArmond, Stephen J.; Wilson, Charles B.

doi:10.3171/jns.1988.68.5.0806

Cited by 44 publications

(39 citation statements)

References 25 publications

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“…The biological behavior of angiosarcomas is not well known because these tumors are among the rarest of human neoplasms 1,2 . The clinical course of primary angiosarcoma of the brain is characterized by the rapid onset of symptoms 2,9 .…”

Section: Discussionmentioning

confidence: 99%

“…The clinical course of primary angiosarcoma of the brain is characterized by the rapid onset of symptoms 2,9 . The diagnosis is usually established by CT scan or magnetic resonance imaging that show well circumscribed tumors with hemorrhage and surrounding edema 2,7 .…”

Section: Discussionmentioning

confidence: 99%

“…Angiosarcoma are rare malignant tumors originating from the endothelial cells of arteries, veins or lymphatic channels 1,2 . This tumor mainly occurs in the head and face, liver, skin and other soft tissues and comprises lower than 1% of all sarcomas [3][4][5][6] .…”

mentioning

confidence: 99%

“…This tumor mainly occurs in the head and face, liver, skin and other soft tissues and comprises lower than 1% of all sarcomas [3][4][5][6] . Cases of primary or secondary angiosarcomas in the central nervous system (CNS) are exceedingly rare malignancies and have previously been reported only exceptionally [1][2][3][4][7][8][9] . We present a case of cerebral metastasis from angiosarcoma of the heart manifested by intracerebral hemorrhage.…”

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confidence: 99%

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Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

Gallo

Dini

Saraiva

et al. 2001

Arq. Neuro-Psiquiatr.

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-The purpose of this article is to describe the clinical and pathological features of metastatic angiosarcoma in the central nervous system. Only a few cases of cerebral metastasis from angiosarcoma of the heart have been recorded in the literature; particulary related to intracerebral hemorrhage. A case of secondary cerebral angiosarcoma of the heart in a 33 years old man is presented. The initial symptoms were headache, vomiting, lethargy and aphasia. There was a mass in the left temporal lobe with hemorrhage and edema on the computerized tomography (CT). After 24 hours the neurological status worsened and another CT scan showed rebleeding on the tumor area. He underwent an emergency craniotomy but died two days after. Considering the longer survival of sarcoma patients with new modalities of treatment, the incidence of brain metastasis may increase, demanding a bether preventive and more aggressive approach. Besides, due to the hemorrhagic nature of such lesions, we suggest the imediate surgery to prevent a fast and lethal evolution because rebleeding.KEY WORDS: brain neoplasm, metastasis, angiosarcoma, heart tumor.Hemorragia em metástase cerebral de angiossarcoma cardíaco: relato de caso RESUMO -O propósito deste artigo é descrever os achados clínicos e patológicos das metástases de angiossarcoma no sistema nervoso central. Apenas poucos casos de metástases cerebrais de angiossarcoma cardíaco foram relatados na literatura, menos ainda relacionados a hemorragia intracerebral. Relatamos o caso de um tumor cerebral secundário a angiossarcoma cardíaco em um paciente masculino de 33 anos. Os sintomas iniciais foram: cefaléia, vômitos, letargia e afasia. A tomografia computadorizada mostrou massa no lobo temporal esquerdo associada a hemorragia e edema. Após 24 horas houve piora do estado neurológico e nova tomografia demonstrou ressangramento no leito tumoral. .oi submetido a uma craniotomia de urgência mas faleceu dois dias após. Considerando a longa sobrevida dos pacientes com sarcoma devido às novas modalidades terapêuticas, poderá aumentar a incidência de metástases cerebrais, necessitando, assim, de melhores métodos preventivos e abordagens cirúrgicas agressivas. PALAVRAS-CHAVES: neoplasia cerebral, metástase, angiossarcoma, tumor cardíaco.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

Gallo

Dini

Saraiva

et al. 2001

Arq. Neuro-Psiquiatr.

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“…Its involvement of the brain, either primary or metastatic, is an extremely rare phenomenon with very few descriptions available in the literatures [1][2][3]7,9,[11][12][13] . When we consider its aggressive biological behavior, such as local invasiveness, high recurrence rate and proximity to the adjacent overlying scalp, its rare incidence is above our apprehension.…”

Section: Introductionmentioning

confidence: 99%

Intracranial Invasion From Recurrent Angiosarcoma of The Scalp

Choi

Chun

et al. 2008

J Korean Neurosurg Soc

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Primary intracranial pleomorphic angioleiomyoma—A New Morphologic Variant. An immunohistochemical and electron microscopic study

Lach

Duncan

Rippstein

et al. 1994

Cancer

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Background. Angioleiomyomas usually are benign subcutaneous neoplasms that occur most often in extremities of middle‐aged individuals. Very few cases have been described in other locations; none along the neuroaxis. An intracranial example of angioleiomyoma displaying unusual morphologic features not seen in the typical peripheral variants of this tumor is described. Methods. The tumor was studied with conventional histology, immunohistochemistry with morphometric calculation of proliferation index, immunoelectron microscopy, and DNA flow cytometry. Results. The tumor was composed of large epithelioid and pleomorphic cells filled with intermediate filaments positive for desmin and vimentin. Scattered cells also expressed myosin and muscle‐specific actin. Smooth muscle cell differentiation was confirmed by ultrastructural demonstration of subplasmalemmal dense bodies, attachment plaques, and discontinuous basal lamina. The proliferation index with proliferating cell nuclear antigen (PCNA) monoclonal antibody was 75.78%, whereas it was only 4.22% with Ki67 monoclonal antibodies adopted to paraffin material (MIB‐1). Conclusion. The tumor represents a unique morphologic variant of a pleomorphic angioleiomyoma. Cellular pleomorphism and a strong reaction for PCNA in numerous cells suggested that the lesion was malignant. However, the absence of mitotic figures, a small number of Ki67‐positive cells, a diploic DNA pattern, and a low proliferation index in flow cytometry all supported the concept that this neoplasm represented an unusual histologic variant of benign angiogenic leiomyoma. Encapsulation and demarcation of the surgical specimen and the survival of the patient for more than 4 years without recurrence after resection support this interpretation.

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Primary cerebral angiosarcoma

Cited by 44 publications

References 25 publications

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

Hemorrhage in cerebral metastasis from angiosarcoma of the heart: case report

Intracranial Invasion From Recurrent Angiosarcoma of The Scalp

Primary intracranial pleomorphic angioleiomyoma—A New Morphologic Variant. An immunohistochemical and electron microscopic study

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