Primary Central Nervous System Lymphoma Revealed by 68Ga-FAPI and 18F-FDG PET/CT

Abstract

A 67-year-old woman presented with left limb weakness, facial paralysis, and unsteady gait for 1 month. Brain MRI detected a mass in the right frontal lobe with prominent peritumoral edema, suggesting a malignant brain tumor. In 18F-FDG PET/CT, the mass was very FDG avid, and 68Ga-FAPI PET/CT showed the mass had heterogeneously mild to moderate increased uptake of the tracer. Histopathological examination after surgical resection of the mass confirmed the diagnosis of diffuse large B-cell lymphoma. The current case indicated the existence of fibrosis in the lymphoma lesion to some extent.

Increased 68Ga-FAPI Uptake in Dermatofibrosarcoma Protuberans

“…Based on PET/CT, the differential diagnoses of dermatofibrosarcoma protuberans include metastasis, lymphoma, Ewing sarcoma, angiosarcoma, and melanoma. It was recently reported that 68 Ga-FAPI might be a potential novel PET agent for imaging tumors because of the overexpression of fibroblast activation protein in cancer-associated fibroblasts 5–9 . Our case indicated that 68 Ga-FAPI might also be valuable in the evaluation of patients with dermatofibrosarcoma protuberans.…”

“…It was recently reported that 68 Ga-FAPI might be a potential novel PET agent for imaging tumors because of the overexpression of fibroblast activation protein in cancer-associated fibroblasts. [5][6][7][8][9] Our case indicated that 68 Ga-FAPI might also be valuable in the evaluation of patients with dermatofibrosarcoma protuberans.…”

Primary Breast Lymphoma Detected by 18F-FDG and 68Ga-DOTA-FAPI-04 PET/CT

“…7 However, some recent cases have shown primary gastric and central nervous system diffuse large B-cell lymphoma had tracer uptake in 68 Ga-FAPI PET/CT, which possibly was due to some degree of fibrosis in the lymphoma. 7,8 Regarding this case, primary breast diffuse large B-cell lymphoma also had tracer accumulation on 68 Ga-DOTA-FAPI-04 PET/CT, which emphasized the potential value of 68 Ga-DOTA-FAPI-04 PET/CT in management of some types of lymphomas.…”

18F-FDG Versus 68Ga-FAPI PET/CT in Visualizing Primary Hepatic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

“…5 Therefore, 68 Ga-FAPI PET/CT may be advantageous for the detection of cerebral, oropharyngeal, and peritoneal involvement of lymphoma lesions. [6][7][8]…”