Primary carcinoid and carcinoma of the rectum occurring simultaneously

A rare case of metachronous neuroendocrine tumor after a colorectal adenocarcinoma: qualitative critical review of synchronous and metachronous gastrointestinal NET

“…To date, the literature in English reveals, 20 case reports (18 synchronous cases [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], 2 metachronous cases [25,26]), 2 case series [25,27], 3 review articles [28][29][30], and about 10 retrospective studies [31][32][33][34] or population-based studies from a National Registry [35][36][37][38][39][40][41] of synchronous or metachronous NET with a second primary malignancy (SPM). A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma (Table 1) and 3 patients (including the present study) of 3 articles with metachronous gastrointestinal NET and colorectal adenocarcinoma ( Table 2).…”

“…Pearson and Fitzgerald were the first to report the high incidence (23%) of second primary malignancies (SPM) in patients with small intestinal NETs at autopsy [27]. A certain number of NETs were incidentally found during surgery for other [7] 1972 53 M Rectum Rectum -Lotlikar et al [25] 1981 53 M Rectum Small bowel -Lotlikar et al [25] 1981 67 F Right colon Small bowel -Lotlikar et al [25] 1981 60 F Sigmoid colon Small bowel -Sacchi et al [8] 1988 57 M Right colon Small bowel -Tse et al [9] 1997 72 M Hepatic flexure Small bowel -Habal et al [28] 2000 52 M Sigmoid colon Rectum Cioffi et al [10] 2005 64 F Ileum Small bowel -Klucinski et al [11] 2006 72 F Transverse colon Small bowel -Chemli et al [12] 2007 63 F Right colon Small bowel -Aslam et al [13] 2009 67 F Sigmoid colon Small bowel G1 Boland et al [14] 2009 77 F Left colon Meckel's diverticulum -McHugh et al [15] 2009 74 F Rectum Small bowel -Wohadlo et al [29] 2011 53 M Splenic-hepatic flexure Small bowel -Gurzu et al [16] 2012 78 F Sigmoid colon Small bowel G3 Pozzato et al [17] 2012 61 M Right colon Duodenum G1 Katalinic 2014 et al [18] 2014 63 M Right colon Meckel's diverticulum G1 Zhu et al [19] 2015 64 F Rectum Rectum G1 Almajano et al [20] 2016 66 M Right colon Small bowel G1 Mohapatra et al [21] 2016 83 M Sigmoid colon Left colon G3 Nejatollahi et al [22] 2016 83 M Sigmoid colon Small bowel G1 Vootla et al [23] 2016 46 F Hepatic flexure Rectum G1 Winn et al [30] 2017 40 M Sigmoid colon Rectum G1 Winn et al [30] 2017 70 M Sigmoid colon Rectum G1 Napolitano et al [24] 2017 72 M Right colon Small bowel G1-G2 cancers. The estimated rate of SPM associated with other malignancies was 2.3% in surgical cases and 8.1% in autopsy cases [42].…”