Concurrent colonic carcinoma and small-bowel carcinoid tumor

Abstract

Recent reviews stressing the existence of synchronous and metachronous noncarcinoid neoplastic lesions in the same segment of an organ stimulated a review of experience with simultaneous small-bowel carcinoids and colonic carcinoma. Four cases of colonic malignancy associated with small-bowel carcinoid are presented. Included are cases with multiple carcinoids and concurrent multiple carcinomas; two metachronous carcinomas with subsequent ileal carcinoids, and three cases explored for colonic carcinoma with the discovery of incidental ileal carcinoids. There are few reports describing this variety of situations. The occurrence of concurrent malignant lesions, particularly more than one metachronous lesion in primary carcinoid cases, is uncommon.

Synchronous ileal carcinoid and primary colonic neoplasms: a case report

“…The synchronous and metachronous midgut carcinoid tumours are usually detected on staging evaluation, surgical exploration, histological examination and autopsies performed for the primary colonic tumours [3,4] The optimum imaging modality depends on whether it is used for detection of primary tumour or for the assessment of the metastasis. Quite contrary to our case, the most midgut carcinoid tumours are not visible on a CT scan, nevertheless the staging CT scan may reveal the presence of lymph nodes enlarged with metastasis from carcinoid cancers [5]. Rarely, the intubation of the terminal ileum on colonoscopy may reveal the incidental ileal carcinoids as described in this case report.…”

A rare case of metachronous neuroendocrine tumor after a colorectal adenocarcinoma: qualitative critical review of synchronous and metachronous gastrointestinal NET

“…To date, the literature in English reveals, 20 case reports (18 synchronous cases [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], 2 metachronous cases [25,26]), 2 case series [25,27], 3 review articles [28][29][30], and about 10 retrospective studies [31][32][33][34] or population-based studies from a National Registry [35][36][37][38][39][40][41] of synchronous or metachronous NET with a second primary malignancy (SPM). A total of 31 patients in 24 articles were included in the study: 28 patients with a synchronous gastrointestinal NET and colorectal adenocarcinoma (Table 1) and 3 patients (including the present study) of 3 articles with metachronous gastrointestinal NET and colorectal adenocarcinoma ( Table 2).…”

A patient with nonfunctional pancreatic neuroendocrine tumor and incidental metachronous colon carcinoma detected by positron emission tomography: Case report

“…Carcinoid tumors are frequently associated with synchronous or metachronous SPM, mainly of the gastrointestinal (GI) and genitourinary (GU) tracts (11)(12)(13)(14)(15)(16)(17), but presence of a SPM in patients with sporadic islet cell tumors is very rare. Sigmoid tumor in a patient with insulinoma (22) and Wilms' tumor in a patient with nonfunctional islet cell tumor (23) were reported.…”

“…There are several reports on the increased risk for a second primary malignancy (SPM) in patients with carcinoid tumors (11)(12)(13)(14)(15)(16)(17), but to our knowledge, no case of colon adenocarcinoma with nonfunctional PNET has been reported previously.…”