Primary bronchogenic squamous cell carcinoma in children: Report of a case and review of the literature

Keita, Olivia; Lagrange, Jean‐Léon; Michiels, J F; Soler, Christine; García, J.M. García; Valla, Jean-Stéphane; Thyss, Antoine

doi:10.1002/mpo.2950240111

Cited by 13 publications

(3 citation statements)

References 6 publications

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“…In adults, squamous cell carcinoma is the second most common type of lung cancer [19]. As of 1995, there were only 6 cases of squamous cell carcinoma of the lung in pediatric patients [20].…”

Section: Discussionmentioning

confidence: 99%

Primary lung tumors in children and adolescents: a 90-year experience

Grabowski

Kozakewich

et al. 2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Primary lung tumors in children and adolescents: a 90-year experience

Grabowski

Kozakewich

et al. 2010

Journal of Pediatric Surgery

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“…These cases included two cases of bronchogenic squamous cell carcinoma [ 6 , 8 ]. Since then only five additional cases of primary brochogenic SCC have been reported, including one case with substantial family history of cancer [[ 3 - 5 , 7 ], and [ 9 ]]. Most of the patients (eight out of nine) are boys.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of lung in a 13-year-old boy: a case report

Wang

Jansen

et al. 2008

Cases Journal

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We are reporting a very rare case of primary bronchogenic squamous cell carcinoma (SCC) with bone metastasis in a 13-year-old boy. A brief review of the English literature on this rare neoplasm in childhood is presented. Case presentationA 13-year-old boy presented with a two-month history of left shoulder pain. Radiographs followed by MRI demonstrated a destructive lesion of the metaphysis of the proximal third of the left humerus [Fig 1]. The metaphysis of the humerus was replaced by a 5-cm tumor. There was some erosion of the cortex with minimal soft tissue extension by the tumor. The initial impression of the lesion was an osteosarcoma, however, an open biopsy revealed metastatic squamous cell carcinoma. The tumor showed islands and nests of squamous cells with a basaloid appearance at the periphery with maturation and squamous pearl formation in the center [Fig 2]. The cells appeared anaplastic with prominent nucleoli, numerous mitoses and focal necrosis [Fig 3].Molecular cytogenetic studies on the tumor were positive for rearrangement of the NUT1 region in 54% of the interphase cells. Additional interphase FISH studies were negative for the NUT/BDR4 fusion. The patient underwent a PET-CT that showed multiple foci of increased uptake in the right upper lobe of the lung. Additional abnormal uptake was also noted at T1, T8, T10, and T11, left proximal humerus, right hilar nodes and right acetabulum. A subsequent chest CT confirmed. the malignant lung neoplasm [ Fig. 4] Since lung cancer is an extremely rare childhood neoplasm, radon tests are performed in the family home and the results were negative. Upon further questioning, a history of lung cancer in both grandmothers was uncovered. One grandfather also had a history of non-Hodgkin lymphoma and pancreatic cancer. The patient was treated with various chemotherapeutic agents. There was no significant clinical improvement and he died one year later. DiscussionPrimary lung cancer is the most frequently diagnosed cancer in the USA and the most common cause of cancer mortality worldwide. It occurs most often between the ages of 40 and 70 years, with a peak incidence in the fifties and sixties. Only 2% of all cases appear before the age of 40. Primary lung cancer in childhood is a rare entity and primary bronchogenic squamous cell carcinoma is extremely rare. To our knowledge, only eight cases of primary bronchogenic squamous cell carcinoma in childhood have been reported in English literature.

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“…Of all reported cases of bronchogenic carcinoma in childhood, only 6 have been of the squamous cell type. 1 Pulmonary neoplasms in children tend to be asymptomatic with the majority of reported cases identified during routine investigation of unrelated medical problems. 2 Given the low index of suspicion for pulmonary malignancies in the pediatric population, the likelihood of progression to advanced stages is increased with such neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Lung With Bony Metastasis in a 13-year-old Boy

Abuzetun

Hazin

Suker

et al. 2008

Journal of Pediatric Hematology/Oncology

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Primary bronchogenic carcinoma of the lung is extremely rare in children, particularly the squamous cell type. Only 6 cases have been reported in the literature. We are reporting a case of metastatic squamous cell carcinoma in a 13-year-old boy who presented with left shoulder pain secondary to bone metastasis. Given the lack of specific symptoms associated with such malignancies, many children are at risk of delayed diagnosis and, as a result, associated metastases. Diagnostic evaluation hinges on biopsy of suspected lesion and histopathologic evaluation. Treatment regimens are rather ill defined, though the mainstay is surgical resection of the lesion along with chemotherapy and palliative radiotherapy for bone metastasis.

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Primary bronchogenic squamous cell carcinoma in children: Report of a case and review of the literature

Cited by 13 publications

References 6 publications

Primary lung tumors in children and adolescents: a 90-year experience

Primary lung tumors in children and adolescents: a 90-year experience

Primary squamous cell carcinoma of lung in a 13-year-old boy: a case report

Primary Squamous Cell Carcinoma of the Lung With Bony Metastasis in a 13-year-old Boy

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