Primary lung tumors in children and adolescents: a 90-year experience

Yu, David C.; Grabowski, Matthew J.; Kozakewich, Harry P.; Perez‐Atayde, Antonio R.; Voss, Stephan D.; Shamberger, Robert C.; Weldon, Christopher B.

doi:10.1016/j.jpedsurg.2010.02.070

Cited by 78 publications

(56 citation statements)

References 26 publications

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“…Primary lung neoplasms are extremely rare in the pediatric population with an overall incidence of less than 0.05 per 100,000 cases [1–4]. According to the World Health Organization (WHO) classification, malignant pulmonary tumors of epithelial origin include non-small cell lung cancer (NSCLC), further subdivided into adenocarcinoma, squamous cell carcinoma, and large-cell carcinoma; other carcinomas of the lung are small cell lung cancer (SCLC) or neuroendocrine tumors [5].…”

Section: Introductionmentioning

confidence: 99%

“…However, the United States Cancer Registry reported that between 1973 and 2011, brain metastases from NSCLC developed in approximately 9% of all pediatric cases [7]. To date, only a few case reports and small case series have been published, and, as such, the treatment choice for lung adenocarcinoma in children is extrapolated from studies in adult patients [1, 2, 4, 8–17]. Here we describe a 10-year-old white girl who presented with brain metastasis from primary pulmonary adenocarcinoma and was treated aggressively, including radiation therapy, for local and distant recurrence and programmed cell death-1 (PD-1) inhibitor therapy.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric lung adenocarcinoma presenting with brain metastasis: a case report

et al. 2018

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BackgroundDiagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma.Case presentationA 10-year-old white girl presented with brain metastases due to primary pulmonary adenocarcinoma. Next generation sequencing analysis with “Comprehensive Cancer Panel” highlighted the presence of multiple non-targetable mutations in the FLT4, UBR5, ATM, TAF1, and GUCY1A2 genes. She was treated aggressively with chemotherapy, surgery, and radiation therapy for local and distant recurrence. Eventually, therapy with nivolumab was started compassionately, and she died 23 months after diagnosis.ConclusionsExtremely rare cancers in children such as lung adenocarcinoma need accurate and specific diagnosis in order to develop an optimal plan of treatment. It is also necessary to underline that “children are not little adults,” thus implying that an adult-type cancer in the pediatric population might have a different etiopathogenesis. Diagnostic confirmation and primary treatment of such rare conditions should be centralized in reference centers, collaborative networks, or both, with multidisciplinary approaches and very specific expertise.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pediatric lung adenocarcinoma presenting with brain metastasis: a case report

et al. 2018

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“…32 Radiotherapy has been demonstrated to have some benefit, mainly in pulmonary IMT. [36][37][38] There is currently no evidence that chemotherapy or radiotherapy have a role for patients following complete resection. Despite the frequently reported use of adjuvant therapy for IMT in the literature, there is no definitive data establishing that it is efficacious and there are no standardized treatment protocols.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Small Bowel Mesentery: An Unusual Cause of Abdominal Pain and Uveitis

Choi

Bohn

Beddow

et al. 2011

Journal of Gastrointestinal Surgery

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“…Subsequently, Hancock et al incorporated an additional 153 cases for a review in 1993 [ 4 ]. Long-term, single-center reviews by Cohen and Kaschula [ 2 ] and subsequently Dishop and Kuruvilla [ 5 ] and Yu et al [ 6 ] have contributed further cases to the literature.…”

Section: Introductionmentioning

confidence: 99%