Primary Breast Lymphoma: Results of a Controlled Clinical Trial

Avilés, Agustín; Delgado, S.; Nambo, M. Jesús; Neri, Natividad; Murillo, Edgar; Cleto, Sérgio

doi:10.1159/000088333

Cited by 186 publications

(241 citation statements)

References 25 publications

(22 reference statements)

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“…It can suggest itself as a primary breast tumor or as an extranodal expression in systemic disease. Since extranodal manifestation is more familiar in non-Hodgkin's lymphoma (NHL) than Hodgkin's disease (HD), with NHLs covering the majority of PBLs [3,4]. Secondary BL (SBL) is more common.…”

Section: Introductionmentioning

confidence: 99%

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Nisar¹,

Khan²,

Nisar³

et al. 2017

J Leuk

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Primary breast lymphoma (PBL) is a unique clinical finding accounting for 0.4-0.5% of all neoplasms in breast with a painless palpable mass being a most common presentation. On histopathological findings and radiological imaging, Diffuse large B-cell lymphoma (DLBCL) is the most widespread identifiable type of PBL. We report a case who presented with Primary breast lymphoma having multiple metastatic lesions in lymph nodes, muscles and bones.

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Section: Introductionmentioning

confidence: 99%

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Nisar¹,

Khan²,

Nisar³

et al. 2017

J Leuk

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“…However, assessment of the association between treatment type and survival was limited due to the retrospective nature of the present study and the limited number of patients included. The only randomized comparison to date demonstrated a significantly improved survival rate in patients who received combined chemotherapy and radiotherapy, compared with chemotherapy or radiotherapy alone (24). In the present study, one patient, who presented with bilateral breast involvement, developed a relapse of the left breast following a lumpectomy and chemotherapy.…”

Section: Discussionmentioning

confidence: 44%

Primary breast lymphoma: A single center study

et al. 2016

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Abstract. The aim of the present study was to summarize the clinical characteristics of primary breast lymphoma (PBL) and evaluate its management approaches. A total of 29 patients newly diagnosed with PBL, and treated between April 2006 and May 2013, were analyzed retrospectively. The median survival follow-up time for all patients was 66.8 (range, 25.4-110.0) months. The results of the follow-up revealed 22 living lymphoma-free patients and 7 patients who had succumbed to PBL. Of the 7 deceased patients, 6 had succumbed to lymphoma and 1 to chemotherapy-associated hepatic failure. In total, 1 patient who presented with bilateral breast lymphoma developed left breast relapse following lumpectomy and chemotherapy, 2 patients developed a bone marrow relapse, 1 patient developed lung and mediastinal lymph node relapses, and 1 patient developed a skin relapse. The Kaplan-Meier estimator predicted 5-year overall survival and progression-free survival rates for all patients of 74.4 and 74.6%, respectively. PBL appears to be a rare disease with a good overall prognosis and low incidence of local relapse, following chemotherapy alone or in combination with other treatments. Further studies investigating the development of effective agents for use in treatment-resistant patients are required.

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“…These patients belonged to the earlier cases, and recently surgery has been largely replaced by medical therapy for treatment of gastric MALToma. 17,18 In conclusion, characteristics abnormal vascular pattern and absence of gastric pits on magnifying endoscopy served as potential features to diagnose gastric MALToma. These features could potentially apply to improve diagnostic accuracy and observe for therapeutic response in patients with gastric MALToma after eradication of H pylori and chemotherapy.…”

Section: Maltoma Was First Described By Isaacson and Wright In 1983mentioning

confidence: 88%

Recognition of changes in microvascular and microstructural patterns upon magnifying endoscopy predicted the presence of extranodal gastric MALToma

Chiu¹,

Wong²,

Teoh³

et al. 2012

jig

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Background and objectives:Gastric MaLToma is difficult to recognize upon endoscopy. The aim of this study is to evaluate the application of microstructural and microvascular patterns in recognizing gastric MaLToma on magnifying endoscopy. Method: all patients with diagnosis of gastric MaLToma upon histology were recruited. They received magnifying endoscopy to observe for changes in microstructural and microvascular patterns. For patients with h pylori, eradication therapy would be given. For those without, appropriate treatments including gastrectomy or chemotherapy were commenced accordingly. patients treated with h pylori eradication and non-operative treatments received follow-up magnifying endoscopy, and the same features were observed to predict the response to these treatments. Results: From 2004 to 2007, nine patients presented to with epigastric pain, dyspepsia and belching. all patients were confirmed to have MaLToma upon initial biopsy. Five patients had h pylori infection and received eradication. Two patients without h pylori were treated with Laparoscopic total gastrectomy. Two patients had pulmonary metastasis and treated with chemotherapy. Under magnifying endoscopy, all the lesions demonstrated either absence or irregular gastric pits. Moreover, there was consistently appearance of spider-shaped vascular pattern. Five patients with h pylori eradication had follow-up magnifying endoscopy, four of them showed resolution of abnormal vascular pattern and recovery of gastric pits. Conclusion: abnormal spider like vasculature and disappearance of gastric pits are diagnostic features upon magnifying endoscopy for gastric MaLToma. These features enhanced the diagnosis and assessment of extent of involvement during primary endoscopy, as well as follow-up surveillance for response to non-operative treatments.

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Primary Breast Lymphoma: Results of a Controlled Clinical Trial

Cited by 186 publications

References 25 publications

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Primary breast lymphoma: A single center study

Recognition of changes in microvascular and microstructural patterns upon magnifying endoscopy predicted the presence of extranodal gastric MALToma

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