Primary Breast Lymphoma: An Uncommon but Curable Disease

Pinheiro, Ronald Feitosa; Colleoni, Gisele W. B.; Baiocchi, Otavio C. G.; Kerbauy, Fábio R.; Duarte, Luiz Cláudio C; Bordin, José Orlando

doi:10.1080/1042819021000040369

Cited by 22 publications

(30 citation statements)

References 12 publications

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“…Edema was manifested as fluid between tissue planes. Numerous hypo echoic areas with thick and irregular walls were observed throughout the breast which indicated abscesses; the largest one measured 77×52×47 mm 3 and its volume was 99 mL. The same findings were observed in the other breast.…”

Section: Case Presentationsupporting

confidence: 70%

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An unusual manifestation of a breast mass: primary lymphoma

Montazer¹,

Farzin²,

Hoseini³

2017

Breast Cancer Rep

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Background: Some of breast masses are uncommon including primary diffuse primary large B-cell lymphoma. It is commonly seen in pregnant and lactating women. It has usually unpleasant symptoms and referred with unspecified diagnosis. The confirmation of diagnosis made by biopsy and patient benefit from radiotherapy and chemotherapy. Methods and materials: In this literature, we report a 41 years old women with several masses in her lactation duration. She had history of 3 cesarean section and seemingly, normal course of pregnancy. Her major chief compliant was painless masses in her breast that initially diagnosed as mastitis. Conclusion:We concluded that occasionally some relatively rare disease such as primary breast lymphoma occurs with unrelated features. Likely, exact obtaining history and physical examination or timely using of imaging and pathology modalities can play important role and help us in guiding treatment.

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Section: Case Presentationsupporting

confidence: 70%

“…The bilateral diffuse type is reported in sporadic cases; it mostly affects pregnant and lactating women with large breasts [2]. The incidence of tumor was 0.04% to 0.5% and it mainly consists of large diffuse cells [3]. Diagnosis is made by biopsy and aspiration.…”

Section: Introductionmentioning

confidence: 99%

An unusual manifestation of a breast mass: primary lymphoma

Montazer¹,

Farzin²,

Hoseini³

2017

Breast Cancer Rep

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“…For many years radiotherapy was considered the treatment of choice [1, 2, 5, 7, 13]. However, no long follow-up is available in most cases and relapse appears to be frequent.…”

Section: Discussionmentioning

confidence: 99%

“…Varying frequencies have been reported, but in most series it is less than 0.7% of all breast malignancies and less than 1% of all non-Hodgkin’s lymphomas. Clinical presentation and radiological findings do not differ from breast cancer and the diagnosis is based on pathological material [1,2,3,4,5,6,7,8]. Different therapeutic approaches have been considered: surgery, radiotherapy, chemotherapy or well-combined two or three therapeutic modalities.…”

Section: Introductionmentioning

confidence: 99%

Primary Breast Lymphoma: Results of a Controlled Clinical Trial

Avilés¹,

et al. 2005

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Objectives: To assess the efficacy and toxicity of the most employed therapeutic approaches in the treatment of primary breast lymphoma (PBL). Methods: Ninety-six patients with PBL in the early stage (I or II) were enrolled to receive radiotherapy (45 Gy); chemotherapy (six cycles of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), every 21 days), or combined therapy. Results: Complete response was achieved in 20 of 30 patients treated with radiotherapy, 19 of 32 who were treated with chemotherapy and 30 of 34 in the combined arm (p < 0.01). Actuarial curves at 10 years showed that event-free survival was 50, 57 and 83%, respectively (p < 0.01). Actuarial curves for overall survival were 50, 50 and 76% (p < 0.01), respectively. The most common site of relapse was the central nervous system. Acute toxicity was mild. Until now, no second neoplasm or acute leukemia has been observed. Conclusions: In our study combined therapy is the best treatment in this special setting of patients; with improvement in event-free survival and overall survival without acute or severe late side effects. Prophylaxis to the central nervous system will be considered in the initial treatment to improve outcome.

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“…Primary lymphoma of the breast (PBL) is a rare disease accounting for 0.5% of breast malignancy and 2.2% of all extranodal lymphomas [1][2][3]. This low incidence may be due to the paucity of lymphoid tissue in the breast [4].…”

Section: Introductionmentioning

confidence: 99%

High Grade Primary Breast Lymphoma: is it a Different Clinical Entity?

Fruchart

Denoux

Chasle

et al. 2005

Breast Cancer Res Treat

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Primary lymphoma of the breast (PBL) is a rare neoplasm, its outcome remains unclear compared to other lymphomas. We performed a retrospective study of 19 cases of high grade PBL. There were 17 Diffuse large B cell lymphoma (DLBCL) and 2 follicular and diffuse grade 3 lymphomas. Four patients were treated with local treatment only, 15 received chemotherapy including 11 treated with CHOP or ACVBP regimens followed by involved field radiotherapy. The actuarial survival for the whole population was 38%. Three of the 4 patients treated only with a local treatment died of their lymphoma. Three patients progressed on therapy and 5 relapsed in the first year of follow-up including 2 central nervous system recurrences. Among the 11 patients treated with chemotherapy, 2 died of their lymphoma. The overall survival of this subgroup was 73% (median follow-up of 57 months). We observed, like others in the literature, a better prognosis for lymphomas co-expressing Bcl6 and CD 10. The treatment should be based on the same modalities, but including a CNS prophylaxis even if poor prognosis factors are lacking. A radical mastectomy increases the risk of treatment failure and has to be avoided.

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Primary Breast Lymphoma: An Uncommon but Curable Disease

Cited by 22 publications

References 12 publications

An unusual manifestation of a breast mass: primary lymphoma

An unusual manifestation of a breast mass: primary lymphoma

Primary Breast Lymphoma: Results of a Controlled Clinical Trial

High Grade Primary Breast Lymphoma: is it a Different Clinical Entity?

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