Primary biliary cirrhosis: Evaluation with T2-weighted MR imaging and MR cholangiopancreatography

Haliloğlu, Nuray; Erden, Ayşe; Erden, İlhan

doi:10.1016/j.ejrad.2007.11.003

Cited by 28 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The signs of portal hypertension are common MRI findings in PBC patients [10,11]. We found ascites, splenomegaly, portosystemic collaterals and portal vein thrombosis in a significant number of patients.…”

Section: Discussionmentioning

confidence: 88%

“…Furthermore, since the majority of patients are asymptomatic when the diagnosis is established with median survival rate of at least 10 years, MRI could be used for long-term follow-up and monitoring disease progression. The role of MRI in the evaluation of PBC patients has already been investigated [5,10,11], but the previously reported studies only included a small number of patients, indicating the need for larger prospective studies with correlation of MRI findings with histological staging.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Integrative role of MRI in the evaluation of primary biliary cirrhosis

et al. 2011

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Integrative role of MRI in the evaluation of primary biliary cirrhosis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Diffuse hepatomegaly was the main pattern of liver morphological changes in PBC[17], and this was related to hyperplasia of the bile duct and cholestasis. This is different from viral hepatitis, where liver volume atrophy is more common.…”

Section: Discussionmentioning

confidence: 99%

The Value of MRI in the Diagnosis of Primary Biliary Cirrhosis and Assessment of Liver Fibrosis

2015

View full text Add to dashboard Cite

ObjectivesTo evaluate MRI findings in patients with primary biliary cirrhosis (PBC) and to determine the value of MRI in the diagnosis of PBC and assessment of liver fibrosis.Materials and MethodsThis study reviewed the prevalence of MRI abnormalities seen in 45 PBC patients in the past four years, including 33 patients who underwent liver biopsy. Correlation between the MRI findings and the pathological stage was determined.ResultsThere were 33 patients who underwent liver biopsy. Twenty-five patients (75.8%) had non-homogeneous changes in the liver signal intensity, 25 (75.8%) had a periportal halo sign, and 29 (87.9%) had lymphadenopathy. The short axis of the enlarged lymph nodes was a mean of 1.2±0.3 cm. A strong positive correlation was observed between histological stage and the inhomogeneity of liver signal intensity (P<0.001). There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001). Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II. There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394).ConclusionMRI is valuable in the diagnosis of PBC, and the periportal halo sign and liver signal intensity help to evaluate the degree of liver fibrosis.

show abstract

“…In contrast, low signal intensity periportal lesions (''periportal halo sign'') on T2weighted MRI/MRCP are caused by periportal edema or periportal lymph fluid accumulation and have been recently reported in patients with PBC and other hepatobiliary conditions. 3 Interestingly, MRI/MRCP findings of all 4 patients with confirmed ErPC on ultrasonography showed no pathological features of the intrahepatic and extrahepatic biliary tree, thus ruling out active PSC as well as periportal fluid accumulation. CEUS with microbubble contrast medium (Sonovue, Bracco, Milan, Italy) showed an unspecific hypoechoic contrast enhancement in both the arterial (5-30 seconds) and the parenchymal phase (3-5 minutes), further supporting the absence of periportal fluid collection.…”

Section: Periportal Cuffing In Inflammatory Bowel Diseases: Mystery Omentioning

confidence: 79%