Periportal Cuffing in Inflammatory Bowel Diseases: Mystery of Stars and Stripes

Neeße, Albrecht; Heumann, Thatcher; Görg, Christian; Kießling, Andreas; Klose, Klaus–Jochen; Gress, Thomas M.; Steinkamp, Martin

doi:10.1002/ibd.21165

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…The disadvantage of this study is that it was performed on a small group of animals, so detailed future studies on a larger number of animals are needed. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Hyperechoic periportal cuffing as an ultrasonographic inflammatory sign in the abdominal pathology of canines

Glăvan¹

2023

IJRRT

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methodsMedical records were analyzed retrospectively in 125 dogs of different breeds and of both sexes, with different clinical signs (abdominal, neurological, systemic), between April 2022 and November 2022. For this, an ultrasound Esaote MyLab ™ Seven (Esaote, UK) device was used, with 2 transducers, convex and linear, with frequency adjusted according to the patient's size, clinical presentation and age. Complete abdominal ultrasound was performed on the included dogs, weighing between 5-25 kg, the population being represented by 87 males and 38 females, aged between 8 months and 13 years.

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Section: Conclusion and Discussionmentioning

confidence: 99%

Hyperechoic periportal cuffing as an ultrasonographic inflammatory sign in the abdominal pathology of canines

Glăvan¹

2023

IJRRT

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“…Currently, surgical resection is the most effective treatment, but only 20% of patients have a resectable tumor at diagnosis (2,3). For patients with borderline resectable tumors, neoadjuvant chemotherapy can sometimes enable downstaging of disease for surgical resection (4,5), but high tissue pressures (on the order of 10-100 mm Hg) can prevent chemotherapeutic agents from reaching the tumor core (6)(7)(8). Leaky vasculature, high stromal density, and high hyaluronic acid content all increase tissue pressure heterogeneously (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Elastography Can Map the Local Inverse Relationship between Shear Modulus and Drug Delivery within the Pancreatic Ductal Adenocarcinoma Microenvironment

Wang

Mislati

Ahmed

et al. 2019

Clinical Cancer Research

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Purpose: High tissue pressure prevents chemotherapeutics from reaching the core of pancreatic tumors. Therefore, targeted therapies have been developed to reduce this pressure. While point probes have shown the effectiveness of these pressure-reducing therapies via single-location estimates, ultrasound elastography is now widely available as an imaging technique to provide real-time spatial maps of shear modulus (tissue stiffness). However, the relationship between shear modulus and the underlying tumor microenvironmental causes of high tissue pressure has not been investigated. In this work, elastography was used to investigate how shear modulus influences drug delivery in situ, and how it correlates with collagen density, hyaluronic acid content, and patent vessel density-features of the tumor microenvironment known to influence tissue pressure.Experimental Design: Intravenous injection of verteporfin, an approved human fluorescent drug, was used in two pancreatic cancer xenograft models [AsPC-1 (n ¼ 25) and BxPC-3 (n ¼ 25)].Results: Fluorescence intensity was higher in AsPC-1 tumors than in BxPC-3 tumors (P < 0.0001). Comparing drug uptake images and shear wave elastographic images with histologic images revealed that: (i) drug delivery and shear modulus were inversely related, (ii) shear modulus increased linearly with increasing collagen density, and (iii) shear modulus was marginally correlated with the local assessment of hyaluronic acid content.Conclusions: These results demonstrate that elastography could guide targeted therapy and/or identify patients with highly elevated tissue pressure.

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“…In comparison, we observed periportal hyperechogenicity in 15 patients with typhoid fever out of 23 patients (65.21%). Neesse et al [9] noticed periportal hyperechogenicity in 4 patients with inflammatory bowel diseases, which disappeared after a few weeks (after remission) and reappeared several weeks later. The authors explained this hyperechogenicity as a possible result of trafficking of the intestinal lymphocytes via the enterohepatic circulation to the portal tracts.…”

Section: Discussionmentioning

confidence: 99%

“…The main pathogenic mechanism of periportal hyperechogenicity is unknown but may be related to one or more of the following: lymphatic stasis, obstruction by edema, or compression from inflammatory or malignant infiltration of the portal tracts [9]; periportal infiltration by inflammatory or malignant cells [5,9]; edema of hepatocytes, causing the liver to appear as hypoechoic in relation to the portal tracts [10]; and depletion of hepatic glycogen and/or fat stores, which may occur in the fasting liver and in depleting diseases [7].…”

Section: Discussionmentioning

confidence: 99%

Transient periportal hyperechogenicity in feverish patients: a novel ultrasonographic finding

2019

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Purpose Periportal hyperechogenicity has been recorded in many inflammatory and infectious diseases, including viral hepatitis, inflammatory bowel diseases, toxic shock syndrome of staphylococcus infection, typhoid fever, and schistosomiasis. We aimed to evaluate the echogenicity of the portal tracts of the liver by abdominal ultrasound imaging in patients with fever irrespective of the cause. Methods Abdominal ultrasound examination was performed in 277 consecutive patients presented with fever at their first visit and repeated 2 weeks later after their recovery. Results Transient periportal hyperechogenicity was present in 39% (108 patients) of the feverish patients studied irrespective of the cause of the fever. Conclusion Transient periportal hyperechogenicity is a frequent ultrasonographic finding in feverish patients irrespective of the cause of fever, and hence should not be misdiagnosed as liver disease or chronic periportal fibrosis unless the hyperechogenicity persists after recovery from the febrile or inflammatory condition.

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Periportal Cuffing in Inflammatory Bowel Diseases: Mystery of Stars and Stripes

Cited by 7 publications

References 8 publications

Hyperechoic periportal cuffing as an ultrasonographic inflammatory sign in the abdominal pathology of canines

Hyperechoic periportal cuffing as an ultrasonographic inflammatory sign in the abdominal pathology of canines

Elastography Can Map the Local Inverse Relationship between Shear Modulus and Drug Delivery within the Pancreatic Ductal Adenocarcinoma Microenvironment

Transient periportal hyperechogenicity in feverish patients: a novel ultrasonographic finding

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