Primary appendiceal lymphoma: clinical characteristics and outcomes of 116 patients

Ayub, Adil; Santana‐Rodríguez, Norberto; Raad, Wissam; Bhora, Faiz Y.

doi:10.1016/j.jss.2016.08.079

Cited by 24 publications

(43 citation statements)

References 22 publications

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“…The most common extranodal lymphoma is diffuse large B cell lymphoma (DLBL), followed by BL. Studies suggest a higher predominance in males (81.9%) and white race (81%), compatible with this case [ 1 ]. BL involves a specific translocation involving the IgH and MYC genes in chromosome 14 and 8, respectively [ 2 ].…”

Section: Discussionsupporting

confidence: 80%

“…Primary appendix neoplasms are uncommon, found in ~0.5–1.0% of appendectomy specimens at pathologic evaluation. Within this group, the appendiceal lymphomas, which are exceedingly rare, constitute around 0.015% of all gastrointestinal lymphoma cases [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Burkitt’s lymphoma (BL) is a mature B-cell non-Hodgkin lymphoma with an aggressive clinical course [ 2 ]. A case series of 116 patients with appendiceal lymphomas determined that BL was the second most prevalent pathology, diagnosed in 25.9% of patients [ 1 ]. This rapidly growing tumor can cause symptoms due to mass effect or direct involvement of the bowel [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Burkitt’s lymphoma presenting as acute appendicitis: a case report

Morais

Mikhael

Németh

et al. 2018

Journal of Surgical Case Reports

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Appendiceal lymphomas are exceedingly rare, constituting around 0.015% of all gastrointestinal lymphoma cases. Burkitt’s lymphoma is the second most prevalent pathology, diagnosed in 25.9% of patients. We report a case of a 36-year-old male admitted with acute abdominal pain with 2 days of evolution, localized in the right lower quadrant associated with hyporexia, but no fever. On examination he presented abdominal tenderness on the right iliac fossa. A diagnosis of acute appendicitis was made clinically. At the post-operative follow up, 2 weeks later, he presented a low back pain of high intensity, associated with swelling of the abdomen, night sweats, daily fevers and weight loss. The histopathological exam of the appendix revealed diffuse and transmural lymphoid proliferation. Immunohistochemistry suggested high grade B-cell lymphoma indicative of Burkitt’s lymphoma. This patient was staged as a IVxB lymphoma and was submitted into polychemotherapy with a complete clinical response in 8 months.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Burkitt’s lymphoma presenting as acute appendicitis: a case report

Morais

Mikhael

Németh

et al. 2018

Journal of Surgical Case Reports

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“…To our knowledge, age was were vital and risk factors for patient with DLBCL in other primary sites. [10,11,14,16] As expected, younger age had more favorable survival than older age in both univariate and multivariate survival analysis, and the optimal cutoff value was identified as 65 year and 75 year. The K-M survival analysis demonstrated that older age was associated with worse prognosis for CSS and OS, with patients more than 75 years having significantly worse prognosis than patients with between 66 and 75 years, with patients under 65 years having better prognosis than patients with between 66 and 75 years.…”

Section: Discussionsupporting

confidence: 65%

“…[9,14] Race was a significantly vital predictor of survival for patients with cancer, [15] but it seems to be not correlated with the prognosis of DLBCL. [13,14,16] In addition, Ann Arbor stage also might be related to overall or cancer-specific prognosis for DLBCL. Therefore, the demographic characteristics and tumor features as prognostic factors must be included in prognostic analysis.…”

Section: Introductionmentioning

confidence: 99%

New nomograms based on treatment outcome and prognostic factors for patients with spinal diffuse large B-cell lymphoma: A population‐based study

Wang¹,

Chen

Xie³

et al. 2020

Preprint

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KEYWORDS spinal diffuse large B-cell lymphoma; Surveillance, Epidemiology, and End Results 2 database; prognostic factors; survival; nomogram. 3 Abstract Background: Spinal diffuse large B-cell lymphoma (DLBCL) is a rare and malignant tumor, while few studies researched the prognostic factors. The prognostic factors which impacts on spinal DLBCL are not clear. Although chemotherapy was recognized as an optimal treatment method, but the curative effect of radiotherapy and surgery were controversial.Methods: The records of patients with spinal DLBCL were selected from the SEER database from 1991 to 2016. The incidence obtained by database was analyzed by Joinpoint Regression Program. The optimal cut-off values of age and year of diagnosis were identified by X-tail program. Univariate and multivariate survival analysis were calculated to identify independent prognostic factors. Prognostic factors were included to predict the survival possibility compared with 5 years of overall (OS) and cancer-specific survival (CSS) via the new nomograms. Results: A total of 917 patients were enrolled. Age, year of diagnosis and chemotherapy were demonstrated as independent prognostic factors for CSS and OS, and primary site was another independent prognostic factor for CSS. However, radiotherapy and surgery might be ineffective in survival. All factors were included to generate the nomograms for CSS and OS. The concordance indices (C-index) for internal validation of OS and CSS prediction were 0.697 (95%CI:

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