Primary Aortic Myxofibrosarcoma Mimicking Thrombus

Abstract

Aortic sarcoma is a rare vascular malignancy. We report a case of primary aortic myxofibrosarcoma mimicking thrombus. This neoplasm demonstrated no contrast enhancement on computed tomography or magnetic resonance imaging and was clinically suspected to represent a large thrombus, although aortic primary neoplasm was considered in the differential diagnosis on the basis of imaging. Biopsies of the aortic lesion and a concurrent brain lesion were consistent with the diagnosis of aortic myxofibrosarcoma with brain metastasis. This report highlights overlapping imaging features between primary aortic sarcoma and vascular thrombus and the importance of considering neoplastic conditions in the differential diagnosis of large intravascular soft tissue lesions.

Primary renal myxofibrosarcoma

“…Cases have been reported in the heart [34], the aorta [6] the thyroid gland [7] and the brain [2]. To the best of our knowledge, our case is the first MFS primary of the kidney to be reported.…”

Low grade myxofibrosarcoma in the right ventricle presenting as pulmonary thromboembolism

“…The left atrium is the most common location (4), followed by the right atrium, right ventricle, and ventricular septum. A rare case of primary myxofibrosarcoma in the aorta has also been reported (5). Myxofibrosarcomas are considered to originate from myofibroblasts.…”

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“…(102) Existen evidencias de una expansión más rápida del aneurisma de aorta abdominal (> 0,4 mm/año) en los pacientes fumadores. (234,235) En general, la terapéutica inicial contempla la utilización de un β-bloqueante para mantener una frecuencia cardiaca 60×' o menor y en aquellos pacientes en quienes no se logra mantener la normotensión, agregar como alternativas un inhibidor de la enzima convertidora de la angiotensina (IECA), un inhibidor de la angiotensina o un bloqueante cálcico.…”