Primary Antibiotic Resistance of
            <i>Helicobacter Pylori</i>
            Among a Chinese Tibetan Population

Tang, Xiaoqiong; Chen, Xiaohong; Shen, Yanjiao; Yang, Tiankuo; Hu, Renwei; Debowski, Aleksandra W.; Stubbs, Keith A.; Benghezal, Mohammed; Marshall, Barry J.; Hong, Liang; Tang, Hong

doi:10.2217/fmb-2020-0206

Cited by 13 publications

(15 citation statements)

References 29 publications

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“…The resistance rate for clarithromycin in our study was 40%, which is in agreement with studies in China (44.4% using disk diffusion and E-tests) 18 and Palestine (47%). 22 Low rates of resistance were reported in Germany (10.9% using PCR) 29 and Cameron (13.57% using disk diffusion).…”

Section: Discussionsupporting

confidence: 91%

“…9 A high resistance rate was also reported also in China (90.6%) using both disk diffusion and the E-test. 18 A moderate resistance rate was detected in France (58.6%) 23 and Korea (27%). 24 The high resistance rates may be due to the widespread use of metronidazole for other infectious diseases, such as parasitic intestinal infections and genital infections.…”

Section: Discussionmentioning

confidence: 96%

“…17 Another study measured a H. pylori culture sensitivity of 29.3% in Chinese patients. 18 The differences in culture sensitivity may be attributed to variations in isolating the organism; success rates depend on the technical expertise of the microbiology laboratory, the adequacy of tissue sampling, the transport media and time, the culture media, and the incubation period.…”

Section: Discussionmentioning

confidence: 99%

“…This rate is similar to the rates reported in Iran (28% using E-test), 28 France (17.6% using PCR), 23 and China (28.2% using disk diffusion and E-test). 18 Zero resistance to levofloxacin was reported in Palestine 22 and Cameron. 9 Although levofloxacin and moxifloxacin are both quinolones, resistance to moxifloxacin was lower in our study (10%).…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study

Metwally¹,

Ragab²,

Hamid³

et al. 2022

IDR

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Helicobacter pylori (H. pylori) is the most common human bacterial infection worldwide, infecting approximately half of the world's population. Although antibiotic use is indicated for H. pylori eradication, the recommended type of antibiotic varies from country to country according to the H. pylori resistance pattern; developing countries, such as Egypt, may have different patterns than developed countries. We evaluated the antibiotic resistance of H. pylori in Egypt. Methods: This cross-sectional study included 134 adult patients with upper gastrointestinal (GI) complaints. Patients with a history of PPI during the last 2 weeks or antibiotics during the last 4 weeks before endoscopy were excluded. Upper GI endoscopies were performed and biopsies were collected for histopathology and H. pylori culture. Demographic, clinical, and endoscopic data were also collected. Antimicrobial susceptibility testing for H. pylori was performed for nine therapeutically relevant antibiotics using the Kirby-Bauer disc diffusion method. Results: The H. pylori antibiotic resistance rates were as follows: moxifloxacin, 10%; doxycycline, 15%; levofloxacin, 20%; clarithromycin, 40%; azithromycin, 40%; erythromycin, 65%; rifampicin, 90%; amoxicillin, 95%; and metronidazole, 100%. Dual resistance rates were 40% for amoxicillin/clarithromycin, 40% for metronidazole/clarithromycin, and 95% for amoxicillin/metronidazole. Conclusion:In Egyptian patients, H. pylori had >90% resistance to metronidazole and amoxicillin; modest resistance to erythromycin, azithromycin, and clarithromycin; and low resistance to moxifloxacin, and levofloxacin (≤20%). Dual resistance was high for amoxicillin/clarithromycin and amoxicillin/metronidazole, which prefers using quinolones rather than clarithromycin or metronidazole for first-line treatment of H. pylori in Egypt.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study

Metwally¹,

Ragab²,

Hamid³

et al. 2022

IDR

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“…For example, in a recent study conducted by our group investigating the antibiotic resistance among 117 Tibetan H . pylori strains, the 7 strains with MIC in the range of 0.19–0.5 mg/L were defined as AML resistant by using MIC >0.125 mg/L as the AML resistance breakpoint 75 . However, if MIC >0.5 mg/L or above was used as AML resistance breakpoint like other studies, 11,12,60,65–69,73 the 7 strains with MIC in the range of 0.19–0.5 mg/L would be redefined as AML susceptible.…”

Section: The Need For Standardization Of Testing Methods and The Harm...mentioning

confidence: 99%

Need for standardization and harmonization of Helicobacter pylori antimicrobial susceptibility testing

Shen

Song

et al. 2022

Helicobacter

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Background and aims As with other infectious diseases, Helicobacter pylori eradication regimens should be guided by susceptibility testing to achieve excellent success rate, especially in the era of high antibiotic resistance. However, susceptibility testing for H. pylori is rarely performed, which can be partly ascribed to the current lack of standardization of testing methods and the lack of unified consensus on the antibiotic resistance breakpoints. The aim of this review was to call for an international consensus on standardization and harmonization of H. pylori susceptibility testing. Methods We summarize and compare the advantages and disadvantages of four different phenotypic antimicrobial susceptibility testing (AST) methods (agar dilution, E‐test, disk diffusion, and broth microdilution) and the molecular susceptibility testing method for H. pylori. Results The standard phenotypic testing methods and the molecular testing methods have their own advantages and disadvantages. Compared to the standard phenotypic methods, the molecular testing method does not require successful H. pylori culture, and therefore, is much more rapid and convenient for clinical use. However, the currently available molecular testing method is only suitable for detecting clarithromycin and quinolone susceptibility profiles in H. pylori. Although the standard AST is time‐consuming, it is currently the only way to test the susceptibility of H. pylori to all the commonly used antibiotics. Conclusion To make H. pylori susceptibility testing become a clinical routine, an international consensus on standardization and harmonization of H. pylori AST is needed. Future efforts are needed for optimizing broth culture of H. pylori, and developing commercial AST plates for achieving high throughput and automated susceptibility testing for H. pylori.

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