PRIMARY AND SECONDARY RESPONSE IN RELATION TO THE INITIAL DETECTION OF ANTI‐Rho (D) IN RH‐NEGATIVE MOTHERS AT RISK

Rh‐Prophylaxis with Immunoglobulin Anti‐D Administered during Pregnancy and after Delivery

“…If we include case AZ in Table I from a previous investigation Rh-immunization or sensitization had occurred in seven out of 586 cases (1.2 per cent). This frequency is in good agreement with those reported by Bartsch and Schneider (1973), Bishop and Krieger (1970), Bowman (1971), Dambrosio (1971), Dudok de Wit (1%8) and Woodrow (1970). Eklund and Nevanlinna (1973) and Freda (1971) report slightly lower frequencies of 0.4 per cent and 0.7 per cent respectively, however.…”

“…Although it wasoncegenerally accepted that Rh-immunization during pregnancy was rare (Nevanlinna & Vaino, 1962), it had been reported that the frequency of this phenomenon was not negligible (Hartmann & Brendemoen, 1953). Later studies have shown that the frequency of Rh-immunization during pregnancy is of the order of 1-3 per cent (Bishop & Krieger, 1970;Bowman, 1971;Chown, 1968;Dambrosio, 1971; Dudok de Witt et al, 1968). A clinical investigation using 250 pg anti-D for prophylaxis of Rh-immunization was started in 1968 at the Clinic of Obstetrics and Gynaecology at Vaxjo in order to find answers to the following questions: ( a ) How many Rh-negative women delivered of Rh-positive babies have antibodies at parturition?…”