Primary and Secondary Bile Acids in Meconium

Sharp, Harvey L.; Peller, Janet D.; Carey, J. D.; Krivit, William

doi:10.1203/00006450-197106000-00005

Cited by 67 publications

(15 citation statements)

References 13 publications

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“…Although bile acid conjugation in normal meconium was more pronounced with taurine than with glycine, in agreement with the results of others,50 51 the predominance of glycine conjugates during ICP found in this study may result from restricted maternal to fetus transport across the placenta for taurine conjugates. With regard to the sulphate conjugated fraction, it has been shown to represent a large proportion of the total bile acids in meconium of newborns from both uncomplicated pregnancies and ICP 52.…”

Section: Discussionsupporting

confidence: 93%

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Rodrigues

Marin

Brites

1999

Gut

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Background-Data on meconium bile acid composition in newborn babies of patients with intrahepatic cholestasis of pregnancy (ICP) are relatively scant, and changes that occur on ursodeoxycholic acid (UDCA) administration have not been evaluated. Aims-To investigate bile acid profiles in meconium of neonates from untreated and UDCA treated patients with ICP. Maternal serum bile acid composition was also analysed both at diagnosis and delivery to determine whether this influences the concentration and proportion of bile acids in the meconium. Patients/Methods-The population included eight healthy pregnant women and 16 patients with ICP, nine of which received UDCA (12.5-15.0 mg/kg body weight/day) for 15±4 days until parturition. Bile acids were assessed in the meconium by gas chromatography-mass spectrometry and in maternal serum by high performance liquid chromatography. Results-Total bile acid and cholic acid concentrations in the meconium were increased (p<0.01) in newborns from patients with ICP (13.5 (5.1) and 8.4 (4.1) µmol/g respectively; mean (SEM)) as compared with controls (2.0 (0.5) and 0.8 (0.3) µmol/g respectively), reflecting the total bile acid and cholic acid levels in the maternal serum (r = 0.85 and r = 0.84, p<0.01). After UDCA administration, total bile acid concentrations decreased in the mother (∼3-fold, p<0.05) but not in the meconium. UDCA concentration in the meconium showed only a 2-fold increase after treatment, despite the much greater increase in the maternal serum (p<0.01). Lithocholic acid concentration in the meconium was not increased by UDCA treatment. Conclusions-UDCA administration does not influence the concentration and proportion of bile acids in the meconium, which in turn are altered by ICP. Moreover, this beneficial treatment for the mother does not increase meconium levels of potentially toxic metabolites of UDCA such as lithocholic acid. (Gut 1999;45:446-452)

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Section: Discussionsupporting

confidence: 93%

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Rodrigues

Marin

Brites

1999

Gut

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“…within the first three days after birth. In analogy to previous data, including biliary and duodenal BSs in preterm and term infants, taurine-conjugated BSs predominated [11,12]. BS conjugation increases hydrophilicity, which promotes aqueous solubility at intestinal pH, and if intravascular, it facilitates renal excretion, thus minimizing the membrane damaging properties of the more hydrophobic unconjugated bile salts [13].…”

Section: Discussionmentioning

confidence: 62%

Fecal Bile Salts and the Development of Necrotizing Enterocolitis in Preterm Infants

et al. 2017

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BackgroundIntestinal bile salts (BSs) may be implicated in NEC development. We hypothesized that fecal BS levels are higher in preterm infants at risk for NEC.MethodsWe compared the composition and concentration of fecal BSs in ten preterm infants who developed NEC (Bell’s Stage ≥ II) with twenty matched control infants without NEC. Conjugated and unconjugated fecal BSs were measured after birth (T1) and twice prior to NEC (T2, T3). Data are presented as medians and interquartile ranges.ResultsGA and BW were similar in all preterms: ~27+4 weeks and ~1010 g. Age of NEC onset was day 10 (8–24). T1 was collected 2 (1–3) days after birth. T2 and T3 were collected 5 (5–6) days and 1 (0–2) day before NEC or at corresponding postnatal ages in controls. The composition of conjugated BSs did not differ between the two groups. Total unconjugated BSs were 3-fold higher before NEC compared to controls at corresponding ages (0.41 μmol/g feces (0.21–0.74) versus 0.14 μmol/g feces (0.06–0.46), p < 0.05).ConclusionFecal BS concentrations are higher in preterm infants who develop NEC compared to infants without NEC. Further study is needed to determine the predictive value of fecal BSs in the development of NEC.

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“…Lithocholic acid, claimed to be present in meconium [9], was found only in one patient. The precursors of these acids are unknown, but it is possible that they are metabolites of the A5 bile acid.…”

Section: Discussionmentioning

confidence: 99%

Excretion of 3β‐hydroxy‐5‐cholenoic and 3a‐hydroxy‐5a‐cholanoic acids in urine of infants with biliary atresia

et al. 1971

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Primary and Secondary Bile Acids in Meconium

Cited by 67 publications

References 13 publications

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Fecal Bile Salts and the Development of Necrotizing Enterocolitis in Preterm Infants

Excretion of 3β‐hydroxy‐5‐cholenoic and 3a‐hydroxy‐5a‐cholanoic acids in urine of infants with biliary atresia

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