Primary Amyloidosis: A Review

Renal Amyloid: A Report on Eleven Cases Proven by Renal Biopsy

“…It is of interest, however, that Case 9 showed extensive deposits of lipid stainable with Oil Red 0 in those parts of the glomeruli which contained amyloid. Most descriptions of the staining properties of amyloid indicate that there is no lipid content (Wagner, 1957;Braunstein and Buerger, 1959), and although Symmers (1956) referred to abundant finely dispersed sudanophil lipid occurring in some amyloid deposits, the amount in the present case was striking. This particular case was one in which there was no antecedent history of any of the diseases usually associated with amyloid.…”

“…The whole problem, with a discussion of so-called primary and secondary amyloidosis, has been fully reviewed in recent years (Symmers, 1956).…”

Localized amyloidosis of the lower respiratory tract

“…Amyloidosis has been classified into (1) primary amyloidosis, which may occur in a systemic or localized form, (2) generalized secondary amyloidosis, and (3) amyloidosis associated with multiple myeloima (Symmers, 1956). Prowse (1958) has emphasized the importance of subdividing amyloidosis of the lower respiratory tract into three groups: (1) multiple amyloid deposits confined to the lung parenchyma; (2) a solitary mass of amyloid affecting a major bronchus; and (3) amyloid deposits involving the wall of many of the air passages (diffuse tracheo-bronchial amyloidosis).…”

Amyloidosis of the Larynx: A Clinicopathologic Study of 11 Cases

“…The second theory for the amyloid deposition suggests that a circulating precursor protein is deposited in the stroma after a change in the vascular permeability as a result of local inflammation (2,9,25,26,30). The plasma cells may be either inciting the inflammation or reacting to the amyloid.…”

“…Hematoxylin and eosin-stained slides for all cases were reviewed to confirm that established histologic criteria for amyloid were met (4,9,13). Congo red and methyl violet stains were performed on 10 cases.…”