Primary alveolar soft part sarcoma of bone

Park, Y. K.; Unni, K. Krishnan; Kim, Y. W.; Han, Chung Soo; Yang, Moon Ho; Wenger, Doris E.; Fh, Sim; Lucas, David R.; Ryan, J.F.; Nadim, Y. A.; Nojima, Takayuki; Fletcher, C. D. M.

doi:10.1046/j.1365-2559.1999.035005411.x

Cited by 44 publications

(25 citation statements)

References 13 publications

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“…Rare locations, where skeletal muscle is absent, are cervix, uterus, orbit, pulmonary vein, stomach and bone [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18]. Recent molecular analyses demonstrated a specific chromosomal translocation of ASPS: der(17)t(X;17)(p11;q25) [19, 20].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, primary bone involvement was also an important prognostic indicator in this series. In a study by Park et al [16], patients with primary ASPS of bone had also a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…ASPS originates most commonly in the deep soft tissue of the lower extremities [1, 2, 3, 4, 5, 6], but it may also arise from the tongue, uterus, stomach, vein and bone [11, 12, 13, 14, 15, 16, 17, 18]. To further elaborate on clinical features, prognostic factors and treatment of ASPS, we performed a retrospective study in patients with ASPS who presented to institutes of the Japanese Musculoskeletal Oncology Group (JMOG).…”

Section: Introductionmentioning

confidence: 99%

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Alveolar Soft Part Sarcoma in Japan: Multi-Institutional Study of 57 Patients from the Japanese Musculoskeletal Oncology Group

Ogose

Yazawa²,

Ueda³

et al. 2003

Oncology

102

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Objective: The clinical features and the management of alveolar soft part sarcoma (ASPS) are not well known. The efficacy of chemotherapy for soft tissue sarcoma, including high-dose ifosfamide and cisplatin, has not been established yet. Some reports suggest ASPS may occur primarily in bone. Methods: We report on a series of 57 patients with ASPS over 20 years. Their ages ranged from 7 to 75 years (mean 25). Results: There were 37 females and 20 males. Thirteen lesions (23%) showed bone involvement at the primary site, and 6 of them were diagnosed as bone tumors at presentation. Thirty-seven patients had distant metastases at presentation. Tumor size, bone involvement at the primary site and the presence of metastases at presentation were prognostic indicators (p < 0.05). Marginal excision with radiotherapy or wide excision without radiotherapy achieved good local control. Chemotherapy was performed in 47 patients with different regimens. Two patients treated with intra-arterial chemotherapy regimens responded partially, but intravenous chemotherapy with high-dose ifosfamide or cisplatin failed. Conclusions: ASPS can present primarily as a bone tumor. No advantage of chemotherapy with high-dose ifosfamide or cisplatin could be demonstrated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alveolar Soft Part Sarcoma in Japan: Multi-Institutional Study of 57 Patients from the Japanese Musculoskeletal Oncology Group

Ogose

Yazawa²,

Ueda³

et al. 2003

Oncology

102

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“…Park and al. [13] The most characteristic finding in ASPS is the consistent demonstration of strong nuclear immunoreactivity for TFE3, reflecting the ASPSCR1-TFE3 fusion gene that had been identified by cytogenetic analysis [4] [14]. Recent studies have shown that the crystals are immunoreactive to a protein MCT1 (monocarboxylate transporter) and to CD 147 [15].…”

Section: Discussionmentioning

confidence: 99%

Primary Alveolar Soft Part Sarcoma of the Scapula

Sahraoui¹,

Boujelbène²,

Doghri³

et al. 2017

OJO

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Alveolar soft-part sarcoma (ASPS) is an uncommon, aggressive soft-tissue neoplasm, occurring in less than 1% of sarcomas. It is typically found in the head and neck tissues in children or in the deep soft tissues of the lower extremities in young adults. This tumor arises primarily within the skeletal muscles or musculofascial planes. Primary involvement of bone is extremely rare. ASPS has poor prognosis with a propensity for recurrence as well as distant metastasis. In this report, we present a 25-year-old male with primary ASPS in the left scapular bone and discuss the histopathological and immunohistochemical features of this sarcoma.

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“…14,30e32 Most bone tumors are found in the long tubular bones and involvement of multiple bones such as the fibula and tibia are also described. 30,32 Distinguishing between bone metastases and primary neoplasms can be difficult; however, cases with primary bone involvement demonstrate cortical bone destruction with ill-defined margins from the soft tissue mass and an epicenter in the bone. These characteristic findings were present in our case, and so a clavicle based primary tumor is considered most likely.…”

Section: Discussionmentioning

confidence: 99%

Clavicular and meningeal alveolar soft part sarcoma: An unusual case and literature review

James

Chang

Levine

et al. 2014

Journal of Orthopaedics

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Primary alveolar soft part sarcoma of bone

Abstract: Alveolar soft part sarcoma arising in bone is extraordinarily rare but should be considered in the differential diagnosis of metastatic hypernephroma in a young patient.

Cited by 44 publications

References 13 publications

Alveolar Soft Part Sarcoma in Japan: Multi-Institutional Study of 57 Patients from the Japanese Musculoskeletal Oncology Group

Alveolar Soft Part Sarcoma in Japan: Multi-Institutional Study of 57 Patients from the Japanese Musculoskeletal Oncology Group

Primary Alveolar Soft Part Sarcoma of the Scapula

Clavicular and meningeal alveolar soft part sarcoma: An unusual case and literature review

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