Primary Advanced Gastric Small Cell Carcinoma

Takaku, Hideya; Oka, Kuniyuki; Naoi, Yoshibumi; Santoh, Norimasa; Setsu, Yasuhiro; Mori, Naoyoshi

doi:10.1111/j.1572-0241.1999.01095.x

American Journal of Gastroenterology

1999

DOI: 10.1111/j.1572-0241.1999.01095.x

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Primary Advanced Gastric Small Cell Carcinoma

Hideya Takaku

Kuniyuki Oka

Yoshibumi Naoi

et al.

Abstract: We report a 73-yr-old man with primary advanced gastric small cell carcinoma, pure type. A large, Borrman type I tumor was located from the cardia to the entire gastric fundus and upper body. Atypical cells showed a round nucleus, small nucleolus, dense to granular chromatin, and scant cytoplasm. The histological findings indicates an advanced stage and exposure to the gastric serosa. Mitotic figures were observed. There was a proliferation of a sheet-like, solid pattern, but no rosette-like, sqamoid, or gland… Show more

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Cited by 3 publications

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Primary small cell carcinoma of the stomach

Kusayanagi¹,

Konishi²,

Miyasaka³

et al. 2003

J of Gastro and Hepatol

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We report on an 80-year-old man with primary gastric small cell carcinoma (SmCC). He was admitted to hospital with hematemesis. An upper gastrointestinal examination revealed an irregularly ulcerated tumor, 60 mm in diameter, on the lesser curvature of the stomach body extending to the cardia. An endoscopic biopsy revealed a solid proliferation of intermediate-sized tumor cells with hyperchromatic nuclei and scanty cytoplasm. Immunohistochemically, the neoplastic cells were positive for neuron-specific enolase and chromogranin A, but negative for carcinoembryonic antigen. No tumor was detected on examination of the chest. Therefore, primary gastric SmCC was diagnosed preoperatively. To date, only 38 cases of primary gastric SmCC, including our case, have been reported. By using endoscopic biopsy, approximately two-thirds of cases have been diagnosed incorrectly. In the reported cases of gastric SmCC, the endoscopic findings frequently indicated a submucosal tumor. Gastric SmCC is clinically aggressive and has an extremely poor prognosis, even when discovered at an early stage. Most patients with gastric SmCC die within 1 year of diagnosis. Although a standard treatment for gastric SmCC has not been established, intensive chemotherapy should be considered to promote long-term survival. We believe that careful examination, including immunohistochemical investigation, is necessary for determining the therapeutic strategy whenever gastric SmCC is suspected during endoscopy.

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Primary small cell carcinoma of the stomach

Kusayanagi¹,

Konishi²,

Miyasaka³

et al. 2003

J of Gastro and Hepatol

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Small-Cell Carcinomas of the Gastrointestinal Tract: A Review

Brenner

Tang

Klimstra

et al. 2004

JCO

255

293

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Small cell carcinoma of the stomach: A report of two cases and a review of the literature

et al. 2018

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Primary small cell gastric carcinomas (SCGC) are rare tumors with an aggressive nature, characterized by early, widespread metastases and poor overall prognosis. SCGC shares similar clinicopathological and molecular characteristics with small cell lung carcinoma and is usually treated in a similar manner. Here, two cases of SCGC in young Caucasian male patients are presented. One patient had metastatic and the other locoregional disease. Multimodal treatment was applied in each case; the resulting survival time was 20.2 months in the patient with initially locoregional disease whereas the remains alive and disease-free 20 months after initial diagnosis. A review of the literature is also presented.

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Primary Advanced Gastric Small Cell Carcinoma

Cited by 3 publications

References 13 publications

Primary small cell carcinoma of the stomach

Primary small cell carcinoma of the stomach

Small-Cell Carcinomas of the Gastrointestinal Tract: A Review

Small cell carcinoma of the stomach: A report of two cases and a review of the literature

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