Small cell carcinoma of the stomach: A report of two cases and a review of the literature

Abstract

Primary small cell gastric carcinomas (SCGC) are rare tumors with an aggressive nature, characterized by early, widespread metastases and poor overall prognosis. SCGC shares similar clinicopathological and molecular characteristics with small cell lung carcinoma and is usually treated in a similar manner. Here, two cases of SCGC in young Caucasian male patients are presented. One patient had metastatic and the other locoregional disease. Multimodal treatment was applied in each case; the resulting survival time was 20.2 months in the patient with initially locoregional disease whereas the remains alive and disease-free 20 months after initial diagnosis. A review of the literature is also presented.

Pathologic Complete Response After Neoadjuvant Chemoradiation in a Patient with Gastric Neuroendocrine Cancer

“…reported that 200 of 205 Chinese patients with gastric small cell cancer underwent surgical resection, which led to a median survival of 46.45 months (range 10-63 months) [15]. Therefore, surgery is considered curative in non-metastatic gastric small cell cancer [9,14-16]. Adjuvant chemotherapy was used in 136 cases, almost all of which received two to six cycles of platinum-based combination chemotherapy [15].…”

“…Table 1 shows case reports and retrospective studies found on gastric neuroendocrine tumors treated with surgery, chemotherapy, and/or radiation. In one of the cases reported by Bakogeorgos et al., a patient with a disseminated disease of gastric neuroendocrine tumor in origin was treated with radiotherapy following etoposide and cisplatin [9]. This patient was reported to be asymptomatic and in remission 20 months after diagnosis.…”

“…On the other hand, type 3 neuroendocrine tumors are composed of poorly differentiated endocrine and exocrine cells, which have a higher malignant potential [6]. There are limited case reports and retrospective series available in the literature that include radiotherapy in the treatment plan for neuroendocrine tumors [7-9]. We describe a case of a malignant neuroendocrine tumor of the stomach, which was successfully treated with neoadjuvant radiation and chemotherapy.…”

Extrapulmonary small cell carcinoma. Literature review

“…МР желудка составляет 0,1-1% всех злокачественных опухолей желудка, 15-20% всех НЭО желудка и 0,1% МРВЛ [20]. Хирургическое лечение рекомендуется использовать при локорегиональных, неметастатических стадиях с обязательной адъювантной ХТ [21][22][23][24].…”