Primary advanced gastric small cell carcinoma A case report and review of the literature

Abstract

We report a 73-yr-old man with primary advanced gastric small cell carcinoma, pure type. A large, Borrman type I tumor was located from the cardia to the entire gastric fundus and upper body. Atypical cells showed a round nucleus, small nucleolus, dense to granular chromatin, and scant cytoplasm. The histological findings indicates an advanced stage and exposure to the gastric serosa. Mitotic figures were observed. There was a proliferation of a sheet-like, solid pattern, but no rosette-like, sqamoid, or glandular patterns. The neoplastic cells were positive for Leu-7 (CD57) and 123C3 (CD56, neural cell adhesion molecule, NCAM) on the surface membrane. We diagnosed this case as primary advanced gastric small cell carcinoma, pure type, and report that Leu-7 and 123C3 monoclonal antibodies are useful markers for gastric small cell carcinoma. The 32 previously reported cases of gastric small cell carcinoma are also reviewed.

Genitourinary Small-Cell Carcinoma: A Single-Institution Experience

“…Regardless of the local modality of therapy (surgery or radiotherapy), the addition of systemic chemotherapy improves outcomes and survival, and therefore chemotherapy should be given whenever possible. Several studies have reported rapid systemic recurrence and an unfavourable outcome with local therapy alone for scc of other sites 20,[29][30][31] . In the present study of gu scc, we found that, compared with patients treated with surgery or radiotherapy alone, patients who received systemic therapy showed a trend toward better survival (12.3 months vs. 6.9 months, p = 0.22) regardless of the primary location, site, and stage of the disease.…”

Gastric Small-Cell Carcinoma Found on Esophagogastroduodenoscopy: A Case Report and Literature Review

“…The initial clinical manifestations of GSCCs are often due to loco-regional disease and thus are indistinguishable from other histologic types arising from the same site. Symptoms can be due to the presence of a mass, ulceration, and bleeding, invasion of adjacent structures, or systemic manifestations of malignancy [1, 5, 8]. GSCC can present with paraneoplastic syndromes, as occurs with small-cell lung cancer (SCLC), and secrete ectopic hormones, such as parathyroid hormone, antidiuretic hormone, calcitonin, or serotonin.…”

An autopsy case of primary small cell gastric carcinoma and adenocarcinoma

“…Microscopically, small cell gastric carcinoma is divided into two types: a pure type and a composite type consisting of glandular and/or squamous differentiation [3]. The pure type was more common (60%) in previous reports [4][5][6].…”