Primary adrenal adult T‐cell leukemia/lymphoma: A case report and review of the literature

Tomoyose, Takeaki; Nagasaki, Akitoshi; Uchihara, Jun-Nosuke; Kinjo, Shigeko; Sugaya, Kimio; Onaga, Tomohiro; Ohshima, Kouichi; Masuda, Masato; Takasu, Nobuyuki

doi:10.1002/ajh.20856

Cited by 14 publications

(11 citation statements)

References 33 publications

(70 reference statements)

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“…Bilateral involvement is seen in 50% of patients [23], and bilateral involvement of the adrenal gland is considered as a single-site extranodal involvement [24]. In the present study, bilateral lesions were seen in 6 patients.…”

Section: Resultsmentioning

confidence: 46%

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

et al. 2014

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BackgroundThe purpose of this study was to define the ultrasound imaging characteristics of adrenal tumors and to assess the performance of ultrasound in differentiating benign ‘leave-alone’ lesions from suspicious lesions.Material/MethodsWe enrolled 882 patients in this study. The nature of each lesion was determined by histopathology. Ultrasound finding of each lesion was compared with its corresponding histopathologic result. The final study group consisted of 911 adrenal masses in 882 patients. All images were reviewed by 2 experienced investigators in a double blind manner.ResultsThere were 553 adenomas identified in the study, which constituted 60.70% of the lesions. There were 161 pheochromocytomas (17.67%), 49 myelolipomas (5.38%), 39 cysts (4.28%), 37 metastasis (4.06%), 35 ganglioneuromas (3.84%), 22 lymphomas (2.41%), and 15 cortical carcinomas (1.65%). The sensitivity, specificity, and accuracy of ultrasound-based diagnosis were 89%, 99%, and 93.9%, respectively. A positive predictive value of 90.9% and a negative predictive value of 94.2% were obtained in this study.ConclusionsThis large-sample study showed that ultrasound was a reliable method in differentiating benign ‘leave-alone’ lesions from suspicious lesions.

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Section: Resultsmentioning

confidence: 46%

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

et al. 2014

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“…Differential diagnoses include cortical adenoma, pheochromocytoma, metastatic-disease, and adrenocorticotropic hormone (ACTH) dependent Cushing’s syndrome [12, 13]. The definitive diagnosis of primary adrenal lymphoma is made by an image-guided percutaneous biopsy, surgical exploration, or a postmortem examination [1, 2, 14]. Histopathologically, the most common type of primary adrenal lymphoma is B-cell type, mainly diffuse large B-cell lymphoma.…”

Section: Discussionmentioning

confidence: 99%

A case report of primary unilateral adrenal NK/T cell lymphoma: good clinical outcome with trimodality treatment

Wang

et al. 2017

BMC Cancer

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BackgroundPrimary natural killer (NK)/T cell lymphoma of adrenal glands is an extremely rare tumor with aggressive clinical behavior. There have only been a few cases reported worldwide and the highest reported survival was 90 days. We report the first case of primary unilateral adrenal NK/T cell lymphoma in China with good outcome.Case presentationThis is a 28-year-old man who presented with abdominal pain and was found to have a large mass on the left adrenal and the top of the renal region. The patient underwent surgical resection and the pathology revealed primary adrenal NK/T cell lymphoma. He received adjuvant sandwich therapy encompassing sequential chemotherapy, radiotherapy and chemotherapy. The patient remains clinically and symptomatically disease-free with over two years follow up.ConclusionGiven the rarity of this disease, there is limited experience with regard to its diagnosis and treatment. This case report will add to the scant literature on this tumor and will be useful for the differential diagnosis and treatment of adrenal disease.

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“…DLBCL is the most common type of PAL (70%), followed by mixed large and small cell, small noncleaved cell, and the undifferentiated type. On immunostaining, the majority of this entity is seen to have originated from B cells [8,9,10,11]. …”

Section: Discussionmentioning

confidence: 99%

“…This decision was based on the results of study LNH87-2 of the Adult Lymphoma Study Group (French: Groupe d’Etudes des Lymphomes de l’Adulte) before the rituximab era [12]. In the literature, about 70 cases were published with rare complete or partial responses, with an overall survival of 4 months [10,11,12,13]. Kim et al reported recent data about 14 PAL patients treated with an R-CHOP regimen.…”

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Lymphoma

Kacem

Zriba

Lakhal

et al. 2014

Tjh

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Primary non-Hodgkin’s lymphoma of the adrenal gland is rare. We report the case of a 56-year-old patient suffering from B symptoms. The CT scan showed a bilateral adrenal mass without any lymph nodes. Scan-guided biopsies led to the diagnosis of diffuse large B-cell lymphoma. The medullar biopsy eliminated a secondary lymphoma. The patient was treated by immunochemotherapy with a complete response before autologous stem cell transplantation.

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Primary adrenal adult T‐cell leukemia/lymphoma: A case report and review of the literature

Cited by 14 publications

References 33 publications

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

Ultrasound Imaging in the Diagnosis of Benign and Suspicious Adrenal Lesions

A case report of primary unilateral adrenal NK/T cell lymphoma: good clinical outcome with trimodality treatment

Primary Adrenal Lymphoma

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