Primary adenoid cystic carcinoma of the bronchus in a female teenager

Masih, Izhaq; Porter, G; Porter, Stephen; Clarke, R. W.; Sidhu, PK; Harney, J.; McCarthy, A.; Convery, Rory P.

doi:10.1136/bcr.08.2010.3252

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…There are case series starting to emerge which show that radiotherapy with an R1 resection can obtain long‐term survival times equivalent to that found in patients with a negative margin resection (R0 resection) . Our case series is supportive of these findings; survival‐free metastasis in patients who underwent R0 resection was 50% ( n = 1/2) at 5 years and 0% ( n = 0/2) at 10 years, compared with 0% ( n = 0/3) at 5 and 10 years for patients who had incomplete resections.…”

Section: Discussionsupporting

confidence: 79%

Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection

Sharma

Gupta

Yaftian

et al. 2019

ANZ Journal of Surgery

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Background: Adenoid cystic carcinoma is a rare cause of thoracic malignancy, and the prognosis may depend on the extent of surgical resection and adjuvant radiotherapy. Complete resection has low rates of local recurrence but is complicated by the involvement of central airways. Adjuvant radiotherapy is frequently recommended but unproven. Methods: We describe the technicalities of radical resection and adjuvant radiotherapy using the primary endpoint of local recurrence and secondary endpoints of locoregional (mediastinal) recurrence and distant metastasis. Resections were classed as microscopically and macroscopically clear (R0) or only macroscopically clear (R1). Results: Twelve patients (eight males) diagnosed between 1999 and 2016, with an average age of 44 AE 12 years, were included. Six of these were operable (operative group), and six had non-resectable lesions (radiotherapy group). In the operative group, three had tracheal disease and three had bronchial disease. Tracheal lesions underwent excision with tracheal anastomosis (all R1 resections). Main bronchial lesions underwent complete excision via pneumonectomy (two R0 and one R1 resections). All these patients received 50-60 Gray of adjuvant radiotherapy. At an average follow-up of 6.1 AE 4.3 years, no patient had local recurrence, two had locoregional recurrence and four had distant metastasis. The radiotherapy group received 60-70 Gray as definitive therapy, and at an average follow-up of 5.4 AE 4.2 years, three had locoregional recurrence and four had distant metastasis. Conclusion: Our case series consolidates evidence that early radical resection and radiotherapy is associated with a low risk of local recurrence in patients with thoracic adenoid cystic carcinoma.

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Section: Discussionsupporting

confidence: 79%

Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection

Sharma

Gupta

Yaftian

et al. 2019

ANZ Journal of Surgery

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“…Adenoid cystic carcinoma of the trachea is relatively rare and tends to occur at younger ages than other neoplasms of the bronchial tree [1,3,4]. At the time of the diagnosis, patients usually present with inspiratory stridor, dyspnea, productive cough [1,3,4,6] or, less frequently, hemoptysis [3,[5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…At the time of the diagnosis, patients usually present with inspiratory stridor, dyspnea, productive cough [1,3,4,6] or, less frequently, hemoptysis [3,[5][6][7]. As dyspnea is generally the initial symptom, it is frequently confused with bronchial asthma, which can cause a delay in diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Adenoid cystic carcinoma (ACC) of the trachea affects men and women equally [2] from the 3rd to 9th decades of life with the mean in the 5th decade [1,3]. However, a case in a 14-year-old girl has been reported [4]. Predisposing factors are not known [1,3] and there is apparently no association between tobacco and adenoid cystic carcinoma [4].…”

Section: Introductionmentioning

confidence: 99%

“…However, a case in a 14-year-old girl has been reported [4]. Predisposing factors are not known [1,3] and there is apparently no association between tobacco and adenoid cystic carcinoma [4]. Due to slow growth [1], initial symptoms can be subtle and go unnoticed or be confused with other obstructive pathologies, such as asthma or chronic obstructive pulmonary disease [1][2][3][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tracheal adenoid cystic carcinoma: A case report

Dionísio¹,

Monteiro²,

Gonçalves³

et al. 2018

Int J Case Rep Images

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Introduction: Adenoid cystic carcinoma is rare in the trachea and, due to slow growth, it can go unnoticed or be confused with other obstructive pathologies for months/years. Case Report: We report a case of a 31-year-old woman who complained of having productive cough, wheezing and dyspnea on exertion with a progressive evolution during months. Bronchial asthma was considered and an inhaled therapy was started. After one month, she denied a significant improvement with treatment, referring inspiratory stridor. Chest X-ray showed a reduction of tracheal diameter in its distal portion and bronchoscopy revealed an extensive mass on the thoracic trachea, reducing the lumen by 80%. Laser therapy for mass resection was performed, leading to recovery of tracheal permeability. Pathological examination revealed to be consistent with adenoid cystic carcinoma.After endoscopic treatment, the patient immediately noticed a relief of symptoms. Conclusion: Due to the extension of

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Adenoid Cystic Carcinoma

Hellquist

Skálová

2014

Histopathology of the Salivary Glands

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Primary adenoid cystic carcinoma of the bronchus in a female teenager

Cited by 8 publications

References 14 publications

Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection

Low recurrence of lung adenoid cystic carcinoma with radiotherapy and resection

Tracheal adenoid cystic carcinoma: A case report

Adenoid Cystic Carcinoma

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