Primary Adenocarcinoma of the Rete Testis With Preceding Detection of Unilateral Hydronephrosis

Abstract

Primary adenocarcinoma of the rete testis is a rare malignant testicular tumor with a poor prognosis. Here we report the case of a 54-year-old man with right hydronephrosis that was detected before the diagnosis of the primary testicular lesion. During the evaluation of the right hydronephrosis by use of abdominopelvic computed tomography, a painless, hard, solid lesion was found on the right testis. The patient underwent radical orchiectomy, and the pathologic examination revealed an adenocarcinoma of the rete testis. Multiple metastases were present at the time of diagnosis. The patient received combined chemotherapy after the surgery but lived only 8 months after the initial diagnosis.

Primary adenocarcinoma of the rete testis with elevation of serum carcinoembryonic antigen: a case report

“…Serum CEA levels were evaluated in 7 case reports [2, 6-10]; 4 of them had elevated serum CEA levels. Three of these cases had metastases at presentation [2,8], and one had local recurrence, retroperitoneal lymph node swelling, and multiple lung metastases 13 months after orchiectomy [9] (Table 1). Three patients with normal serum CEA levels were alive during the observation period [6,7,10].…”

“…Three patients with normal serum CEA levels were alive during the observation period [6,7,10]. In four cases with immunostaining for CEA, the tumor cells were positive for CEA [2,6,8]. Thus, CEA might be a biomarker that reflects the progression of adenocarcinoma of the rete testis.…”

KMT2C mutation in a Chinese man with primary multidrug-resistant metastatic adenocarcinoma of rete testis: a case report

“…In addition, no statistically significant differences in survival between patients who received adjuvant chemotherapy and those who did not were found ( p = 0.6), although Shunsuke Owa et al [ 13 ] reported that a patient with metastatic AORT did not progress for 7 months and survived for 20 months after 7 cycles of platinum-based combined chemotherapy. Most previous reports indicate poor responses to traditional chemotherapy by metastatic cases [ 14 ]. Consistent with these findings, the current patient developed multiple metastases to the lung and thoracic vertebra during the two cycles of platinum-based combined chemotherapy and showed resistance to second- and third-line chemotherapy regimens.…”