Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection

Ribeiro, Hériks Gomes; Dantas-Komatsu, Raquel Costa Silva; Medeiros, Jeane Franco Pires; Carvalho, Maria Clara da Cruz; Soares, Victor de Lima; Reis, Bruna Zavarize; Luchessi, André Ducati; Silbiger, Vivian Nogueira

doi:10.1016/j.cca.2021.08.003

Cited by 6 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, none of the studies reviewed presented data on vitamin D status. Therefore, our results confirm that the metabolic status assessment remains important in the prognosis of these patients and in the risk of infection [30]. Our findings may have important implications in daily clinical practice, indeed, the prompt identification of patients with pre-existing MetS remains critical to promptly identify vulnerable populations who would require prioritization in treatment and prevention, and close monitoring if infected.…”

Section: Discussionsupporting

confidence: 76%

Prognostic Role of Metabolic Syndrome in COVID-19 Patients: A Systematic Review Meta-Analysis

Zuin

Rigatelli

Bilato

et al. 2021

Viruses

View full text Add to dashboard Cite

Background: The prevalence and prognostic implications of metabolic syndrome (MetS) in patients infected by the SARS-CoV-2 remain unclear. We performed a systematic review and meta-analysis of prevalence and mortality risk in COVID-19 patients with MetS. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE and Scopus to locate every article published up to 1 September 2021, reporting data on MetS among COVID-19 patients. The pooled prevalence of MetS was calculated using a random effects model and presented using the related 95% confidence interval (CI), while the mortality risk was estimated using the Mantel-Haenszel random effects models with odds ratio (OR) and related 95% CI. Statistical heterogeneity was measured using the Higgins I2 statistic. Results: Six studies, enrolling 209.569 COVID-19 patients [mean age 57.2 years, 114.188 males (54.4%)] met the inclusion criteria and were included in the final analysis. The pooled prevalence of dyslipidaemia was 20.5% of cases (95% CI: 6.7–47.8%, p = 0.03), with high heterogeneity (I2 = 98.9%). Pre-existing MetS was significantly associated with higher risk of short-term mortality (OR: 2.30, 95% CI: 1.52–3.45, p < 0.001), with high heterogeneity (I2 = 89.4%). Meta-regression showed a direct correlation with male gender (p = 0.03), hypertension (p < 0.001), DM (p = 0.01) and hyperlipidaemia (p = 0.04), but no effect when considering age (p = 0.75) and chronic pulmonary disease (p = 0.86) as moderators. Conclusions: MetS represents a major comorbidity in about 20% of COVID-19 patients and it is associated with a 230% increased risk of short-term mortality.

show abstract

Section: Discussionsupporting

confidence: 76%

Prognostic Role of Metabolic Syndrome in COVID-19 Patients: A Systematic Review Meta-Analysis

Zuin

Rigatelli

Bilato

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…A higher proportion of patients with the Omicron variant had abnormally elevated total cholesterol and low-density lipoprotein than in patients with Delta. Dyslipidemia is a potential risk factor for COVID-19 ( 27 ). Studies have shown that Dyslipidaemia was associated with the severity and mortality of COVID-19 ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical characteristics between SARS-CoV-2 Omicron variant and Delta variant infections in China

Liu²,

Li³

et al. 2022

Front. Med.

View full text Add to dashboard Cite

BackgroundThe continued ‘evolution’ of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the emergence of the Omicron variant after the Delta variant, resulting in a significant increase in the number of people with COVID-19. This increase in the number of cases continues to have a significant impact on lives. Therefore, a more detailed understanding of the clinical characteristics of Omicron infection is essential.MethodsUsing medical charts, we extracted clinical information for 384 patients infected with the Omicron variant in Anyang City, Henan Province, China. Epidemiology and clinical characteristics were compared with a cohort of people infected with the Delta variant in Zhengzhou in 2021.FindingsCommon initial symptoms at onset of illness were cough [240 (63%)], expectoration [112 (29%)], fever [96 (25%)], nasal congestion [96 (25%)] and myalgia or fatigue [30 (6%)]. In patients with the Omicron variant, levels of total cholesterol, low-density lipoprotein and creatinine increased in 52 (14%), 36 (9%) and 58 (15%) patients, respectively, compared with patients with the Delta variant [one (1%), one (1%) and two (2%)]. Levels of triglyceride and high-density lipoprotein also increased. In patients with the Omicron variant, the levels of specific gravity and the erythrocyte sedimentation rate were increased in 115 (30%) and 81 (21%) patients, and serum levels of complement 3 decreased in 93 (41%).ResultsCompared with patients infected with Delta, no major differences in initial clinical symptoms were identified in patients infected with Omicron. However, dyslipidemia and kidney injury were much more severe in patients with the Omicron variant, and the erythrocyte sedimentation rate was increased. Due to decreased levels of complement 3, the immunity of patients with the Omicron variant was weak.

show abstract

“…Impact Factor of these journals are 4.546 and 5.032, respectively. The 29 studies were carried out between the years 2020 and 2021, with twenty published in the year 2021 ( 25 – 30 , 34 – 39 , 42 , 46 , 47 , 49 – 53 ) and nine published in the year 2020 ( 31 – 33 , 36 , 38 , 40 – 42 , 48 ) ( Table 1 ). Of these, 8 studies investigated electronic health record data or biobank data obtained prior to the COVID-19 pandemic ( 33 , 34 , 36 , 41 , 43 , 45 , 48 , 52 ).…”

Section: Resultsmentioning

confidence: 99%

“…Only 23% of all COI (3/13) were due to direct funding to carry out the study ( 39 , 41 , 49 ). Authors of two of these studies ( 39 , 41 ) stated that the sponsoring company did not play a role in the selection or methodological evaluation of the included studies, nor in the interpretation of the results or conclusions reached.…”

Section: Resultsmentioning

confidence: 99%

Conflict of Interests in the Scientific Production on Vitamin D and COVID-19: A Scoping Review

Passini

Cavalcanti

Ribas

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

The use of scientific evidence to support the process of formulating and implementing public policies might be biased by studies funded by the pharmaceutical and food industry, which more often than not meet corporate interests. This review aimed to analyze the occurrence of conflict of interest (COI) in academic production regarding vitamin D and COVID-19, considering the facility offered during the pandemic for academic publications of heterogeneous quality. A scoping review of observational studies published in Medline, Lilacs, and Google Scholar databases was carried out. The selected studies were published between December 2019 and August 2021, focused on the relationship between vitamin D and prevention or treatment of COVID-19 in non-institutionalized individuals, with no language restrictions. Twenty-nine studies met eligibility criteria. COI was disclosed in five papers and further identified by review authors in eight other papers, meaning COI was present in thirteen papers (44.8%). Studies were funded by companies in the diagnostics, pharmaceutical and food sectors. Conclusions favorable to vitamin D supplementation were more prevalent in papers where COI was identified (9/13, 69.2%) than among papers where COI was not found (4/16, 25.0%). Omissions of disclosure of COI, funding source, and sponsor functions were observed. The identification of possible corporate political activities in scientific papers about vitamin D published during the COVID-19 pandemic signals a need for greater transparency and guideline development on the prevention of COI in scientific production.

show abstract

Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection

Cited by 6 publications

References 45 publications

Prognostic Role of Metabolic Syndrome in COVID-19 Patients: A Systematic Review Meta-Analysis

Prognostic Role of Metabolic Syndrome in COVID-19 Patients: A Systematic Review Meta-Analysis

Comparison of clinical characteristics between SARS-CoV-2 Omicron variant and Delta variant infections in China

Conflict of Interests in the Scientific Production on Vitamin D and COVID-19: A Scoping Review

Contact Info

Product

Resources

About