Previous Pregnancy as a Protective Factor Against Death From Melanoma

Hersey, Peter; Stone, Daniel E.; Morgan, Gareth; McCarthy, William H.; Milton, G. W.

doi:10.1016/s0140-6736(77)91943-2

Cited by 77 publications

(31 citation statements)

References 6 publications

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“…The x2 value for the comparison of Rhand Rh+ parous women was 1X95 (P< 0 20). These latter data are similar to our previous published data on the effect of parity on survival from melanoma (Hersey et al, 1977).…”

Section: Comparison Of the Survival Of Rh-and Rh+ Melanoma Patientssupporting

confidence: 92%

Relationship of natural killer-cell activity to rhesus antigens in man

Hersey¹,

Edwards²,

Trilivas³

et al. 1979

Br J Cancer

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Summary.-A number of previous studies have shown that the level of natural killer (NK) cell activity in humans is relatively constant for a given individual but varies widely between individuals. The factors which determine this variability are largely unknown, but genetic factors appear to be involved. In the present study it was found that Rh-normal subjects and melanoma patients had significantly higher natural cytotoxicity to target cells than Rh+ patients. This difference did not appear to be due to sensitization against Rh antigens on the target cell and may indicate that genes determining NK-cell activity are associated with those determining the expression of Rh antigens.Analysis of the survival data for Rh-and Rh+ patients did not reveal any increase in survival attributable to the higher natural cytotoxicity in Rh-patients.

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Section: Comparison Of the Survival Of Rh-and Rh+ Melanoma Patientssupporting

confidence: 92%

Relationship of natural killer-cell activity to rhesus antigens in man

Hersey¹,

Edwards²,

Trilivas³

et al. 1979

Br J Cancer

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“…On the other hand, many nulliparous patients are unmarried and, for various reasons, late tumour detection or delayed doctor's attendance may occur. This possibly accounts for the better prognosis for parous women in the series of Hersey et al (1977) and Shaw et al (1978). The present analysis was unable to show any disparity in survival after evidence of distant metastasis between parous aiid nulliparous women.…”

Section: Discussioncontrasting

confidence: 74%

“…Reports on the role of previouts pregnancies are conflicting (Hersey et al, 1977;Shaw et al, 1 978;Weiss & Flannery, 1978). The effect of previous gestation might, be immunological (immunization against tumour-associated foetal antigens?)…”

Section: Discussionmentioning

confidence: 99%

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Malignant melanoma: sex differences in survival after evidence of distant metastasis

Rampen¹

1980

Br J Cancer

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Summary.-Survival data of 106 males and 110 females with disseminated malignant melanoma, recorded between 1956 and 1975, were reviewed. Survival after first evidence of distant metastasis was significantly longer in women than in men (P=0.02). There was no difference in survival after occurrence of distant metastasis between pre-and postmenopausal women, nor between parous and nulliparous women. However, there was a clear female superiority of premenopausal women over males <50 years and, to a lesser extent, of postmenopausal women over males >50 years. It is concluded that endocrine factors enhance melanoma activity in the male patient. The suggestion that malignant melanoma is "testosterone-dependent" seems justifiable. A possible explanation is given for the general experience that women with melanoma show a more favourable response to chemotherapy than men.

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“…The question as to whether pregnancy and childbirth may influence the survival of patients with melanoma has been a topic of interest for some years, and several studies have found that pregnancies before diagnosis are conducive to a relatively favourable prognosis in melanoma (Shaw et al, 1978, Hersey et al, 1977. However, an equal or greater number have found no difference, or a worse survival in women with prior pregnancies (Elwood & Coldman, 1978;Weiss & Flannery, 1978; Lee & Hill, 1970).…”

Section: Discussionmentioning

confidence: 99%