Previous Nutritional State and Glucose Conversion to Fatty Acids in Liver Slices

Ej, Masoro; Chaikoff, I.L.; Chernick, Sidney S.; Felts, J.M.

doi:10.1016/s0021-9258(18)56376-6

Cited by 217 publications

(2 citation statements)

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“…The overshoot in the activity of the citrate-cleavage enzyme is much greater than that observed for the acetate thiokinase. These changes in enzyme activity parallel the inhibition of fatty acid synthesis that occurs on starvation, and the exceptionally large increases in fatty acid synthesis that occur when starved animals are re-fed with diets high in carbohydrate and low in fat (Boxer & Stetten, 1944;Bernhard & Steinhauser, 1944;Bloch, 1948;Shapiro & Wertheimer, 1948;Masoro, Chaikoff, Chernick & Felts, 1950;Medes, Thomas & Weinhouse, 1952;Hutchens, Van Bruggen, Cockburn & West, 1954;Miller, Cooper & Freeman, 1957;Emerson, Bernards & Van Bruggen, 1959;Tepperman & Tepperman, 1958a,b, 1961Cockburn & Van Bruggen, 1959;Masoro & Porter, 1960;Langdon, 1960;Fritz, 1961;Spencer et al 1964). Acetyl-CoA carboxylase and the enzymes of the fatty acid-synthetase complex show similar changes in activity (Gibson & Hubbard, 1960;Numa, Matsuhashi & Lynen, 1961;.…”

Section: Resultsmentioning

confidence: 98%

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Citrate and the Conversion of Carbohydrate Into Fat. The Activities of Citrate-Cleavage Enzyme and Acetate Thiokinase in Livers of Starved and Re-Fed Rats

Kornacker¹,

Lowenstein²

1965

Biochemical Journal

200

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1. The activity of citrate-cleavage enzyme varies in accordance with the nutritional state of the animal. It is suppressed on starvation and restored on re-feeding after starvation. 2. The increase in enzyme activity that occurs on re-feeding starved animals depends on the diet. It is largest on diets high in carbohydrate and low in fat, and smallest on diets high in fat. Intermediate increases are obtained with balanced diets. 3. The ratio of activities of citrate-cleavage enzyme to acetate thiokinase varies from 2.5 for animals maintained on a balanced diet to 20 for animals re-fed with a diet high in carbohydrate. 4. The changes in activity of citrate-cleavage enzyme correlate with changes in the rate of fatty acid synthesis and provide evidence for the involvement of the citrate-cleavage reaction in fatty acid synthesis.

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Section: Resultsmentioning

confidence: 98%

“…The rate of fatty acid synthesis is regulated by both the fat and the carbohydrate content of the food. The higher the fat content, and the lower the carbohydrate content, the lower the rate of fatty acid synthesis (Masoro et al 1950;Hausberger & Milstein, 1955).…”

Section: Resultsmentioning

confidence: 99%