“…The overshoot in the activity of the citrate-cleavage enzyme is much greater than that observed for the acetate thiokinase. These changes in enzyme activity parallel the inhibition of fatty acid synthesis that occurs on starvation, and the exceptionally large increases in fatty acid synthesis that occur when starved animals are re-fed with diets high in carbohydrate and low in fat (Boxer & Stetten, 1944;Bernhard & Steinhauser, 1944;Bloch, 1948;Shapiro & Wertheimer, 1948;Masoro, Chaikoff, Chernick & Felts, 1950;Medes, Thomas & Weinhouse, 1952;Hutchens, Van Bruggen, Cockburn & West, 1954;Miller, Cooper & Freeman, 1957;Emerson, Bernards & Van Bruggen, 1959;Tepperman & Tepperman, 1958a,b, 1961Cockburn & Van Bruggen, 1959;Masoro & Porter, 1960;Langdon, 1960;Fritz, 1961;Spencer et al 1964). Acetyl-CoA carboxylase and the enzymes of the fatty acid-synthetase complex show similar changes in activity (Gibson & Hubbard, 1960;Numa, Matsuhashi & Lynen, 1961;.…”