Previous adaptation triggers distinct molecular pathways and modulates early and long-term neuroprotective effects of pregnancy swimming preventing neonatal hypoxia-ischemia damage in rats

Pregnancy swimming prevents early brain mitochondrial dysfunction and causes sex-related long-term neuroprotection following neonatal hypoxia-ischemia in rats

“…Before matings, adult female rats (around 90-old days age) were randomly distributed into 2 groups, namely swimming (SW, n = 12) and sedentary (SE, n = 15). SW animals had 7 sessions of adaptation to training with increased time exposure to the tank, as previously described (Sanches et al, 2020). Pregnancy was confirmed by the presence of spermatozoids in the vaginal smear; this was considered as gestational day (GD0).…”